Protein Overview: FMS1

General Information:
Name(s) found:	FMS1 / YMR020W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|798930\|emb\|CAA89122.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6323662\|ref\|NP_013733.1\| Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Fms1p [Saccharomyces cerevisiae] [NCBI NR] gi\|1706879\|sp\|P50264.1\|FMS1_YEAST RecName: Full=Polyamine oxidase FMS1; AltName: Full=Fenpropimorph resistance multicopy suppressor 1 [NCBI NR] gi\|1143556\|emb\|CAA57442.1\| FMS1 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S54021 FMS1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] Polyamine oxidase FMS1 OS=Saccharomyces cerevisiae GN=FMS1 PE=1 SV=1 [Swiss-Prot] FMS1 Protein involved in the biosynthesis of pantothenic acid [mips] Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis [SGD] FMS1, Chr XIII from 315376-316902 [yeast_orfs2] Chr XIII from 315376-316902 [yeastorf3.fasta] (P50264) FMS1 protein [4932.FASTACCERV.txt] FMS1 SGDID:S0004622, Chr XIII from 315376-316902, Verified ORF [yeastflysequest.fasta] Fms1p [Saccharomyces cerevisiae]gi\|798930\|emb\|CAA89122.1\| unknown [Saccharomyces cerevisiae]gi\|1143556\|emb\|CAA57442.1\| FMS1 [Saccharomyces cerevisiae]gi\|1077976\|pir\|\|S54021 FMS1 protein - yeast (Saccharomyces cerevisiae)gi\|1706879\|sp\|P50264\|FMS1_YEAST [nrdb_11152004_Chlamydomonas] FMS1 SGDID:S000004622, Chr XIII from 315376-316902, Verified ORF, "Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthes [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Polyamine oxidase FMS1 (Fenpropimorph resistance multicopy suppressor 1) [nr-271106-contam.fasta] Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Fms1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] FMS1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] FMS1 SGDID:S000004622, Chr XIII from 315376-316902, Verified ORF, "Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Polyamine oxidase FMS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FMS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] FMS1 SGDID:S000004622, Chr XIII from 315377-316903, Genome Release 64-1-1, Verified ORF, "Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis" [yeast-030211-contam.fasta] FMS1 SGDID:S000004622, Chr XIII from 315377-316903, Genome Release 64-2-1, Verified ORF, "Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis" [20141208_orf_trans.fasta] YMR020W SGDID:S000004622, Chr XIII from 315377-316903, Genome Release 64-1-1, Verified ORF, "Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	508 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	pantothenate biosynthetic process [IMP] polyamine catabolic process [IGI][IMP]
Molecular Function:	amine oxidase activity [IDA][IGI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTVSPAKKK VIIIGAGIAG LKAASTLHQN GIQDCLVLEA RDRVGGRLQT VTGYQGRKYD  60
   61 IGASWHHDTL TNPLFLEEAQ LSLNDGRTRF VFDDDNFIYI DEERGRVDHD KELLLEIVDN 120
  121 EMSKFAELEF HQHLGVSDCS FFQLVMKYLL QRRQFLTNDQ IRYLPQLCRY LELWHGLDWK 180
  181 LLSAKDTYFG HQGRNAFALN YDSVVQRIAQ SFPQNWLKLS CEVKSITREP SKNVTVNCED 240
  241 GTVYNADYVI ITVPQSVLNL SVQPEKNLRG RIEFQPPLKP VIQDAFDKIH FGALGKVIFE 300
  301 FEECCWSNES SKIVTLANST NEFVEIVRNA ENLDELDSML EREDSQKHTS VTCWSQPLFF 360
  361 VNLSKSTGVA SFMMLMQAPL TNHIESIRED KERLFSFFQP VLNKIMKCLD SEDVIDGMRP 420
  421 IENIANANKP VLRNIIVSNW TRDPYSRGAY SACFPGDDPV DMVVAMSNGQ DSRIRFAGEH 480
  481 TIMDGAGCAY GAWESGRREA TRISDLLK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		FMS1 FUS3 RTT109 VPS75

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	APC5	FMS1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..89] [102..295] [439..508]	PSI-BLAST	177.67837	Polyamine oxidase
2	View Details	[90..101] [296..438]	PSI-BLAST	177.67837	Polyamine oxidase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2