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Protein Overview: ITT1

General Information:
Name(s) found: ITT1 / YML068W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 464 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: regulation of translational termination [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALTQFENDL EILRDMYPEL EMKSVKVEEE GEFPQRINGK LLFKISLLAD VNIEFGEQHM  60
   61 LLSNLSNECV EFTIYSCHYP DIRRCVVMDI KSLWISTDEK KMLIDKALRL VEETVDMSIE 120
  121 FADSFTSILI LIFGFLIDDT AILLFPNGIR KCLTQDQYDL FKQISEEATL QKVSRSNYHC 180
  181 CICMEMEKGV RMIKLPCENA NVEHYLCRGC AKSYFTAMIQ ENRISSVRCP QCEYKELKLE 240
  241 DFKSYKKMLK ALFTPLIPVS FLKEVIDTEL CERYEKMFYN QAATRLSKYC PYACVTCRRC 300
  301 DSWCTKEDLD DAMIQCQKCH FVFCFDCLHA WHGYNNKCGK KVSLSTDIIE EYLDDTVTSY 360
  361 ERKRKLEAKY GRRVLELEVN DYLAEKMLDL AIKKEGSNLQ RCPKCKVVVE RSEGCNKMKC 420
  421 EVCGTLFCFI CGVLLYPEDP YEHFREAYSG CYGRLFEGMP GTET

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YOR203W ITT1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] MSA 2.045993 View MSA. No confident structure predictions are available.
    2 View Details [78..153] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [154..251] MSA 7.120997 View MSA. No confident structure predictions are available.
    4 View Details [252..338] Pfam 18.920819 IBR domain No confident structure predictions are available.
    5 View Details [339..464] Pfam 2.075721 IBR domain No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.65442784325159 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.55686022186257 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.59153177011595 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.07217714843839 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.32056863527247 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91926431269551 bayes_pls_golite062009
  • DNA binding
    		•  1.67694054164995 bayes_pls_golite062009
  • protein binding
    		•  1.5975811408548 bayes_pls_golite062009
  • ligase activity
    		•  1.36029325773279 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.04179360284548 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • transcription factor activity
    		•  0.942440775656356 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.260419630474309 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.251823232412941 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.120138679619734 bayes_pls_golite062009
    3
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.65442784325159 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.55686022186257 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.59153177011595 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.07217714843839 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.32056863527247 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91926431269551 bayes_pls_golite062009
  • DNA binding
    		•  1.67694054164995 bayes_pls_golite062009
  • protein binding
    		•  1.5975811408548 bayes_pls_golite062009
  • ligase activity
    		•  1.36029325773279 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.04179360284548 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • transcription factor activity
    		•  0.942440775656356 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.260419630474309 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.251823232412941 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.120138679619734 bayes_pls_golite062009
    4
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.65442784325159 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.55686022186257 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.59153177011595 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.07217714843839 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.32056863527247 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91926431269551 bayes_pls_golite062009
  • DNA binding
    		•  1.67694054164995 bayes_pls_golite062009
  • protein binding
    		•  1.5975811408548 bayes_pls_golite062009
  • ligase activity
    		•  1.36029325773279 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.04179360284548 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • transcription factor activity
    		•  0.942440775656356 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.260419630474309 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.251823232412941 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.120138679619734 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle