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View Structure Prediction Details

Protein: ITT1
Organism: Saccharomyces cerevisiae
Length: 464 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ITT1.

Description E-value Query
Range		 Subject
Range
ITT1_YEAST - Translation termination inhibitor protein ITT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
ITT1 - Protein that modulates the efficiency of translation termination, interacts with translation release...
 1.0E-98 [1..464] [1..464]
RNF14_MOUSE - E3 ubiquitin-protein ligase RNF14 OS=Mus musculus GN=Rnf14 PE=1 SV=2
 2.0E-63 [7..459] [10..462]
RNF14 - ring finger protein 14
 1.0E-62 [7..459] [10..461]
itt1 - ubiquitin-protein ligase E3
ITT1_SCHPO - E3 ubiquitin-protein ligase itt1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=itt1 PE=3...
 5.0E-60 [8..460] [16..425]
ari-1 - status:Partially_confirmed UniProt:O01965 protein_id:AAB93645.3
 1.0E-57 [41..453] [3..329]

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Predicted Domain #1
Region A:
Residues: [1-77] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALTQFENDL EILRDMYPEL EMKSVKVEEE GEFPQRINGK LLFKISLLAD VNIEFGEQHM  60
   61 LLSNLSNECV EFTIYSC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [78-153] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYPDIRRCVV MDIKSLWIST DEKKMLIDKA LRLVEETVDM SIEFADSFTS ILILIFGFLI  60
   61 DDTAILLFPN GIRKCL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.841 0.088 regulation of translational termination a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.65442784325159 bayes_pls_golite062009
small conjugating protein ligase activity 5.55686022186257 bayes_pls_golite062009
acid-amino acid ligase activity 4.59153177011595 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.32056863527247 bayes_pls_golite062009
nucleic acid binding 1.91926431269551 bayes_pls_golite062009
DNA binding 1.67694054164995 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
ligase activity 1.36029325773279 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.04179360284548 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
transcription factor activity 0.942440775656356 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.260419630474309 bayes_pls_golite062009
transcription repressor activity 0.251823232412941 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription cofactor activity 0.120138679619734 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [154-251] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQDQYDLFKQ ISEEATLQKV SRSNYHCCIC MEMEKGVRMI KLPCENANVE HYLCRGCAKS  60
   61 YFTAMIQENR ISSVRCPQCE YKELKLEDFK SYKKMLKA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.65442784325159 bayes_pls_golite062009
small conjugating protein ligase activity 5.55686022186257 bayes_pls_golite062009
acid-amino acid ligase activity 4.59153177011595 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.32056863527247 bayes_pls_golite062009
nucleic acid binding 1.91926431269551 bayes_pls_golite062009
DNA binding 1.67694054164995 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
ligase activity 1.36029325773279 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.04179360284548 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
transcription factor activity 0.942440775656356 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.260419630474309 bayes_pls_golite062009
transcription repressor activity 0.251823232412941 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription cofactor activity 0.120138679619734 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [252-338] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFTPLIPVSF LKEVIDTELC ERYEKMFYNQ AATRLSKYCP YACVTCRRCD SWCTKEDLDD  60
   61 AMIQCQKCHF VFCFDCLHAW HGYNNKC

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 18.920819
Match: PF01485
Description: IBR domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.65442784325159 bayes_pls_golite062009
small conjugating protein ligase activity 5.55686022186257 bayes_pls_golite062009
acid-amino acid ligase activity 4.59153177011595 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.32056863527247 bayes_pls_golite062009
nucleic acid binding 1.91926431269551 bayes_pls_golite062009
DNA binding 1.67694054164995 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
ligase activity 1.36029325773279 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.04179360284548 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
transcription factor activity 0.942440775656356 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.260419630474309 bayes_pls_golite062009
transcription repressor activity 0.251823232412941 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription cofactor activity 0.120138679619734 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [339-464] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKKVSLSTDI IEEYLDDTVT SYERKRKLEA KYGRRVLELE VNDYLAEKML DLAIKKEGSN  60
   61 LQRCPKCKVV VERSEGCNKM KCEVCGTLFC FICGVLLYPE DPYEHFREAY SGCYGRLFEG 120
  121 MPGTET

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 2.075721
Match: PF01485
Description: IBR domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle