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Protein Overview: LEU3

General Information:
Name(s) found: LEU3 / YLR451W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 886 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: leucine biosynthetic process [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGRSDFVAT SQSGSEMSHS ETRNRTGMNA RKRKFACVEC RQQKSKCDAH ERAPEPCTKC  60
   61 AKKNVPCILK RDFRRTYKRA RNEAIEKRFK ELTRTLTNLT SDEILKKIEE EQEIVLDNSN 120
  121 FTKEKVKQLR KSAFETTEIE PRSYKTLRGE PISYSTNRRH TDSSPLTLLS SSTNFDPVHS 180
  181 TNVMTDDQLK CLPKSLGDVY LSSSDIAELF QEFATKYHQF LPVVDLSKGA ERIYHLSPCL 240
  241 FWVILLIGLR RKFGATDLMT RLSVLVKSVL SEITISPIIR YTPSDKDEPV LNVASVYSVQ 300
  301 AFLLYTFWPP LTSSLSADTS WNTIGTAMFQ ALRVGLNCAG FSKEYASANS ELVNEQIRTW 360
  361 ICCNVVSQTV ASSFGFPAYV SFDYLVISSI RVPNSKSQVD IPNELRQMAQ IARFENQIVN 420
  421 TMNSTPASVT GMVSQEEKQP LLHVLNQQLS QLEISLEENN LDDIRKFLLL VAKVHLLTYY 480
  481 FTDVTSQSAG KSNGNIYEGS YSIMELDTSF ETKRGLVKVY NAAVNFLIHA NSMWEHDPTI 540
  541 IKYFPGLFVL NIWQSACIIS KLIHSSLHSM LDVNSGKKAY NNAISLTFNA SVLKYDMAYR 600
  601 SSGIMRSIWS LFANMYDAWK NDQKEGGGRL NNDFNLGITI KSRMSVNVFF DCLYILKEKC 660
  661 GMAKLERETK VSTAYNVDEE EEEDEDEEGE EEEEEEELSS KVPENMDSQQ LRTRKFTNVR 720
  721 HPEKKARKII ETIPLDPNPI NAGSTSSGSS LTTPNSQVAN TISYRGILNK MSPREQLNHA 780
  781 NLDSSVSTDI KDTEAVNEPL PIGRNAEHPA NQPPLSITQM QENTLPATQA NSSLLETYPI 840
  841 VQSNPVTTTI KESPNSIMAG WDNWESDMVW RDVDILMNEF AFNPKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LEU3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 10.522879 Hap1 (Cyp1); HAP1
    2 View Details [107..491] MSA 4.14298 View MSA. No confident structure predictions are available.
    3 View Details [492..886] deduced N/A No confident structure predictions are available.
    4 View Details [494..668] MSA 1.244992 View MSA. No confident structure predictions are available.
    5 View Details [669..886] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle