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View Structure Prediction Details

Protein: LEU3
Organism: Saccharomyces cerevisiae
Length: 886 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEU3.

Description E-value Query
Range
Subject
Range
LEU3 - Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynth...
LEUR_YEAST - Regulatory protein LEU3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU3 PE=1 SV=1
0.0 [1..886] [1..886]
gi|2262187 - gi|2262187|gb|AAB63563.1| FacB [Aspergillus niger]
2.0E-78 [29..517] [16..520]
gi|2262191 - gi|2262191|gb|AAB63565.1| acetate regulatory DNA binding protein FacB [Emericella nidulans]
gi|67516815, gi|... - gi|67516815|ref|XP_658293.1| hypothetical protein AN0689.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
7.0E-74 [30..509] [17..513]
gi|2262189 - gi|2262189|gb|AAB63564.1| FacB [Aspergillus oryzae]
7.0E-71 [30..507] [17..506]
gi|10998378 - gi|10998378|gb|AAG25917.1|AF190427_1 putative GAL4-like transcriptional activator [Colletotrichum li...
3.0E-62 [19..535] [3..520]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
7.0E-62 [18..488] [20..527]
ACU15_NEUCR - Transcriptional activator protein acu-15 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS ...
ACU15_NEUCR, AC1... - Transcriptional activator protein acu-15 OS=Neurospora crassa GN=acu-15 PE=1 SV=2, (P87000) Transcri...
2.0E-60 [29..518] [16..511]
THI1_SCHPO - Thiamine repressible genes regulatory protein thi1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2...
thi1 - transcription factor Thi1
6.0E-60 [18..488] [20..527]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGRSDFVAT SQSGSEMSHS ETRNRTGMNA RKRKFACVEC RQQKSKCDAH ERAPEPCTKC  60
   61 AKKNVPCILK RDFRRTYKRA RNEAIEKRFK ELTRTLTNLT SDEILK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1hwtD_
Description: Hap1 (Cyp1); HAP1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [107-491]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIEEEQEIVL DNSNFTKEKV KQLRKSAFET TEIEPRSYKT LRGEPISYST NRRHTDSSPL  60
   61 TLLSSSTNFD PVHSTNVMTD DQLKCLPKSL GDVYLSSSDI AELFQEFATK YHQFLPVVDL 120
  121 SKGAERIYHL SPCLFWVILL IGLRRKFGAT DLMTRLSVLV KSVLSEITIS PIIRYTPSDK 180
  181 DEPVLNVASV YSVQAFLLYT FWPPLTSSLS ADTSWNTIGT AMFQALRVGL NCAGFSKEYA 240
  241 SANSELVNEQ IRTWICCNVV SQTVASSFGF PAYVSFDYLV ISSIRVPNSK SQVDIPNELR 300
  301 QMAQIARFEN QIVNTMNSTP ASVTGMVSQE EKQPLLHVLN QQLSQLEISL EENNLDDIRK 360
  361 FLLLVAKVHL LTYYFTDVTS QSAGK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [492-886]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNGNIYEGSY SIMELDTSFE TKRGLVKVYN AAVNFLIHAN SMWEHDPTII KYFPGLFVLN  60
   61 IWQSACIISK LIHSSLHSML DVNSGKKAYN NAISLTFNAS VLKYDMAYRS SGIMRSIWSL 120
  121 FANMYDAWKN DQKEGGGRLN NDFNLGITIK SRMSVNVFFD CLYILKEKCG MAKLERETKV 180
  181 STAYNVDEEE EEDEDEEGEE EEEEEELSSK VPENMDSQQL RTRKFTNVRH PEKKARKIIE 240
  241 TIPLDPNPIN AGSTSSGSSL TTPNSQVANT ISYRGILNKM SPREQLNHAN LDSSVSTDIK 300
  301 DTEAVNEPLP IGRNAEHPAN QPPLSITQMQ ENTLPATQAN SSLLETYPIV QSNPVTTTIK 360
  361 ESPNSIMAGW DNWESDMVWR DVDILMNEFA FNPKV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [494-668]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNIYEGSYSI MELDTSFETK RGLVKVYNAA VNFLIHANSM WEHDPTIIKY FPGLFVLNIW  60
   61 QSACIISKLI HSSLHSMLDV NSGKKAYNNA ISLTFNASVL KYDMAYRSSG IMRSIWSLFA 120
  121 NMYDAWKNDQ KEGGGRLNND FNLGITIKSR MSVNVFFDCL YILKEKCGMA KLERE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [669-886]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKVSTAYNVD EEEEEDEDEE GEEEEEEEEL SSKVPENMDS QQLRTRKFTN VRHPEKKARK  60
   61 IIETIPLDPN PINAGSTSSG SSLTTPNSQV ANTISYRGIL NKMSPREQLN HANLDSSVST 120
  121 DIKDTEAVNE PLPIGRNAEH PANQPPLSIT QMQENTLPAT QANSSLLETY PIVQSNPVTT 180
  181 TIKESPNSIM AGWDNWESDM VWRDVDILMN EFAFNPKV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle