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Protein Overview: SEC72

General Information:
Name(s) found: SEC72 / YLR292C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 193 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [TASLink to PubMed article]
    Sec62/Sec63 complex [IPILink to PubMed article]
    Biological Process: posttranslational protein targeting to membrane [TASLink to PubMed article]
    Molecular Function: protein transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTLEYNANS KLITASDAVV ALSTETNIDQ INVLTTSLIG ETNPNFTPQP NEALSKMIKG  60
   61 LFESGMKNLQ QKKLNEALKN VSLAIEMAQR KRAPWEAFAI QLPELHFMLR SKIDLCLILG 120
  121 KHLEALQDLD FLLGTGLIQP DVFVRKADCL LKLRQWEEAR ATCERGLALA PEDMKLRALL 180
  181 IETARNLAEY NGE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SEC62 SEC63 SEC66 SEC72
    View Details (MIPS) Mewes HW, et al. (2004) SEC62 SEC63 SEC66 SEC72
    View Details Krogan NJ, et al. (2006) SEC63 SEC66 SEC72
    View Details Gavin AC, et al. (2006) SEC62 SEC63 SEC66 SEC72
    View Details Gavin AC, et al. (2002) ANP1 FKS1 MNN10 SEC62 SEC63 SEC66 SEC72
    View Details Qiu et al. (2008) SBH1 SBH2 SEC61 SEC62 SEC63 SEC66 SEC72 SSH1 SSS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CMD1 SEC72 1 Unpublished Fields Lab Data
    View Screen EUG1 SEC72 1 Unpublished Fields Lab Data
    View Screen SPO21 SEC72 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC72 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [140..193] Pfam 4.823909 Tetratricopeptide repeat No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.91163869511795 bayes_pls_golite062009
  • binding
    		•  1.76895296443793 bayes_pls_golite062009
  • signal sequence binding
    		•  0.791153798439582 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle