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Protein Overview: ECM22

General Information:
Name(s) found: ECM22 / YLR228C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; homologous to Upc2p; relocates from intracellular membranes to perinuclear foci on sterol depletion [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 814 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: sterol biosynthetic process [IMPLink to PubMed article]
    Molecular Function: RNA polymerase II transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSDDGNAGQ EREKDAELIE VGGKKVSKTS TGKRKFHNKS KTGCDNCKRR RVKCDEGKPF  60
   61 CKKCTNMKLD CVYSPIQPRR RKDSSSSKFA SAVHDRVGKK NLSDNAIMLQ QQQQQLHHQQ 120
  121 EQQFRQQQQV QLQQQLLPHV GTDEQSNSPN SVPPSVSNNM ENLLLPHLLA SLVNNTSNST 180
  181 NSSANGAEAH NNITQTAPSS MINNNHPNMA LPGNSPLSIP ITPSFQSTAM NLSSSLNGLL 240
  241 SPGRLNSVTN GLQQPQLQQQ NQQIPQQQGT QSPFSNIPFD QLAQLNKMGL NFNMKSFNTL 300
  301 FPYGAANGMA SEFQELFGLG KFATSNNRAI KVSTAEEALA NMQQEQEDKN KQFTKNPLDN 360
  361 TKTDAVNSGN NPLNGNENKV TASDILSHNK NLIIDNTGLT ISPPHTLSKP SIDQNIASPS 420
  421 TGVSNVTSTK SLLSIPDNRT ALGNSPTLKT SPMGDLLSNS EALSPRSSNS HTQQQSSPHS 480
  481 NASSASRLVP ELVGLSRKSN LNLIDLKLFH HYCTDVWHTI TEAGISGPEV WSTYIPDLAF 540
  541 HFPFLMHTIL AFSATHLSRT EAGLDNYVSS HRLEALRLLR EAVLEISDDN TDALVASALI 600
  601 LILDSLANAS SSSPTAWIFH VKGAVTILTA VWPLSETSKF YNLISVDLSD LGEAVINQSN 660
  661 HNNDNDNSNN GDGNNNNTIS ELVCFDESIA DLYPVEIDSP YLITLAYLDK LHREKNQLDF 720
  721 MLRVFSFPAL LDRTFLALLM TGDLGAMRIM RSYYTLLRGY TTEIKDKVWF LDSVSQVLPQ 780
  781 DVDEYSGGGG MHMMLDFLGG GLPSMTTTNF SAFM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SMC5 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ECM22 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161] PSI-BLAST 54.927757 PPR1
    2 View Details [162..547] ab initio 8.46 No description for 1i3qA was found.
    3 View Details [548..656] MSA 1.00397 View MSA. Confident ab initio structure predictions are available.
    4 View Details [657..814] deduced N/A Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle