YRC Public Data Repository - Protein Structure Prediction

Protein:	ECM22
Organism:	Saccharomyces cerevisiae
Length:	814 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECM22.

Description	E-value	Query Range	Subject Range
gi\|44985775 - gi\|44985775\|gb\|AAS54399.1\| AGL091Wp [Ashbya gossypii ATCC 10895] gi\|45201005, gi\|... - gi\|45201005\|ref\|NP_986575.1\| AGL091Wp [Ashbya gossypii ATCC 10895], gi\|44985775\|gb\|AAS54399.1\| AGL09...	514.0	[0..1]	[814..41]
UPC2 - Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of... UPC2_YEAST - Sterol uptake control protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UPC2 PE=... gi\|151942193 - gi\|151942193\|gb\|EDN60549.1\| transcription factor [Saccharomyces cerevisiae YJM789]	477.0	[0..262]	[813..375]
gi\|49640315 - gi\|49640315\|emb\|CAH02772.1\| KLLA0A04169p [Kluyveromyces lactis] gi\|50302499, gi\|... - gi\|50302499\|ref\|XP_451184.1\| unnamed protein product [Kluyveromyces lactis], gi\|49640315\|emb\|CAH0277...	475.0	[0..7]	[813..16]
gi\|49524530 - gi\|49524530\|emb\|CAG58132.1\| unnamed protein product [Candida glabrata] gi\|50285595, gi\|... - gi\|50285595\|ref\|XP_445226.1\| unnamed protein product [Candida glabrata], gi\|49524530\|emb\|CAG58132.1\|...	463.0	[0..97]	[814..171]
FA5_PIG - Coagulation factor V OS=Sus scrofa GN=F5 PE=2 SV=1	390.0	[0..4]	[530..943]
gi\|163040 - gi\|163040\|gb\|AAA30513.1\| factor V	388.0	[0..4]	[505..942]
gi\|4503643, gi\|1... - gi\|4503643\|ref\|NP_000121.1\| coagulation factor V precursor [Homo sapiens], gi\|182798\|gb\|AAB59532.1\| ...	376.0	[0..4]	[526..960]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSDDGNAGQ EREKDAELIE VGGKKVSKTS TGKRKFHNKS KTGCDNCKRR RVKCDEGKPF  60
   61 CKKCTNMKLD CVYSPIQPRR RKDSSSSKFA SAVHDRVGKK NLSDNAIMLQ QQQQQLHHQQ 120
  121 EQQFRQQQQV QLQQQLLPHV GTDEQSNSPN SVPPSVSNNM E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.927757
Match:	1pyiA
Description:	PPR1
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [162-547]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLLLPHLLAS LVNNTSNSTN SSANGAEAHN NITQTAPSSM INNNHPNMAL PGNSPLSIPI  60
   61 TPSFQSTAMN LSSSLNGLLS PGRLNSVTNG LQQPQLQQQN QQIPQQQGTQ SPFSNIPFDQ 120
  121 LAQLNKMGLN FNMKSFNTLF PYGAANGMAS EFQELFGLGK FATSNNRAIK VSTAEEALAN 180
  181 MQQEQEDKNK QFTKNPLDNT KTDAVNSGNN PLNGNENKVT ASDILSHNKN LIIDNTGLTI 240
  241 SPPHTLSKPS IDQNIASPST GVSNVTSTKS LLSIPDNRTA LGNSPTLKTS PMGDLLSNSE 300
  301 ALSPRSSNSH TQQQSSPHSN ASSASRLVPE LVGLSRKSNL NLIDLKLFHH YCTDVWHTIT 360
  361 EAGISGPEVW STYIPDLAFH FPFLMH

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	8.46
Match:
Description:	No description for 1i3qA was found.

Predicted Domain #3

Region A:
Residues: [548-656]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TILAFSATHL SRTEAGLDNY VSSHRLEALR LLREAVLEIS DDNTDALVAS ALILILDSLA  60
   61 NASSSSPTAW IFHVKGAVTI LTAVWPLSET SKFYNLISVD LSDLGEAVI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.958	N/A	N/A	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Predicted Domain #4

Region A:
Residues: [657-814]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQSNHNNDND NSNNGDGNNN NTISELVCFD ESIADLYPVE IDSPYLITLA YLDKLHREKN  60
   61 QLDFMLRVFS FPALLDRTFL ALLMTGDLGA MRIMRSYYTL LRGYTTEIKD KVWFLDSVSQ 120
  121 VLPQDVDEYS GGGGMHMMLD FLGGGLPSMT TTNFSAFM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.923	a.118.8	TPR-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits