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Protein Overview: DPH5

General Information:
Name(s) found: DPH5 / YLR172C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 300 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: peptidyl-diphthamide biosynthetic process from peptidyl-histidine [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: diphthine synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYLIGLGLS YKSDITVRGL EAIKKCSRVY LEHYTSILMA ASQEELESYY GKEIILADRE  60
   61 LVETGSKQIL NNADKEDVAF LVVGDPFGAT THTDLVLRAK REAIPVEIIH NASVMNAVGA 120
  121 CGLQLYNFGQ TVSMVFFTDN WRPDSWYDKI WENRKIGLHT LVLLDIKVKE QSIENMARGR 180
  181 LIYEPPRYMS IAQCCEQLLE IEEKRGTKAY TPDTPAVAIS RLGSSSQSFK SGTISELANY 240
  241 DSGEPLHSLV ILGRQCHELE LEYLLEFADD KEKFGKDVAN DQEYFKPAAW VPPTEDDSDE 300
  301

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DPH5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] PSI-BLAST 36.30103 Cobalt precorrin-4 methyltransferase CbiF
    2 View Details [114..300] PSI-BLAST 36.30103 Cobalt precorrin-4 methyltransferase CbiF


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle