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Protein Overview: SMF3

General Information:
Name(s) found: SMF3 / YLR034C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 473 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    Biological Process: intracellular sequestering of iron ion [IMPLink to PubMed article]
    Molecular Function: iron ion transmembrane transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSYMQILQK FAKFIGPGIL VSVAYMDPGN YATSVSGGAQ YKYTLLFSIF ISNIFAVLLQ  60
   61 CLCVKLGTIT GYDLAENCRH NLPKKLNYTL YLFAEVAIIA TDLAEVVGTA IALQILFKIP 120
  121 LTWGVLLTVL DVLVILMFYT PNGQSLKKVR VFEFGVGILV IGTCICFVLE LFKVSIPDKA 180
  181 ELFKGFLPSN IIFKEQQALY ISLGILGATV MPHSLYLGSS IVKPRLHDYD LKKYGKVNAR 240
  241 PSLSAIKYTL NYAYAELIIS LFLIATFVNS AILIVAGATL SGQPEAEDAD LLSIYKLLVH 300
  301 YISPAAGLIF ALAMLCSGQS AGIICTLAGQ IVSEGFLQWS LPPWATRLCT RLIAIVPCLF 360
  361 VTLTMGEKGI SDILNFSQVV LSLILPIVSA PLIYFTANRK LMVVHDENGV VRAPADVNAI 420
  421 ADETTPLNSK HSKIVDFTNS RLLTYTSVFV WALIGSLNCY LVISYLLGAD IHF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BMS1 BPL1 RCL1 RNT1 SMF3
    View Details Qiu et al. (2008) CCC1 PMC1 SMF3 VCX1 VMA9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SMF3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..473] Pfam 226.017729 Natural resistance-associated macrophage protein No confident structure predictions are available.
    2 View Details [211..260] MSA 1.278995 View MSA. No confident structure predictions are available.
    3 View Details [261..338] MSA 2.27999 View MSA. No confident structure predictions are available.
    4 View Details [339..473] MSA 5.268997 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle