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Protein Overview: FPS1

General Information:
Name(s) found: FPS1 / YLL043W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    fungal-type vacuole [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: glycerol transport [IDALink to PubMed article]
    response to arsenic [IGILink to PubMed article][IMPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    conjugation with cellular fusion [IMPLink to PubMed article]
    transport [ISSLink to PubMed article]
    Molecular Function: glycerol transmembrane transporter activity [IDALink to PubMed article]
    transporter activity [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNPQKALND FLSSESVHTH DSSRKQSNKQ SSDEGRSSSQ PSHHHSGGTN NNNNNNNNNN  60
   61 NSNNNNNGND GGNDDDYDYE MQDYRPSPQS ARPTPTYVPQ YSVESGTAFP IQEVIPSAYI 120
  121 NTQDINHKDN GPPSASSNRA FRPRGQTTVS ANVLNIEDFY KNADDAHTIP ESHLSRRRSR 180
  181 SRATSNAGHS ANTGATNGRT TGAQTNMESN ESPRNVPIMV KPKTLYQNPQ TPTVLPSTYH 240
  241 PINKWSSVKN TYLKEFLAEF MGTMVMIIFG SAVVCQVNVA GKIQQDNFNV ALDNLNVTGS 300
  301 SAETIDAMKS LTSLVSSVAG GTFDDVALGW AAAVVMGYFC AGGSAISGAH LNPSITLANL 360
  361 VYRGFPLKKV PYYFAGQLIG AFTGALILFI WYKRVLQEAY SDWWMNESVA GMFCVFPKPY 420
  421 LSSGRQFFSE FLCGAMLQAG TFALTDPYTC LSSDVFPLMM FILIFIINAS MAYQTGTAMN 480
  481 LARDLGPRLA LYAVGFDHKM LWVHHHHFFW VPMVGPFIGA LMGGLVYDVC IYQGHESPVN 540
  541 WSLPVYKEMI MRAWFRRPGW KKRNRARRTS DLSDFSYNND DDEEFGERMA LQKTKTKSSI 600
  601 SDNENEAGEK KVQFKSVQRG KRTFGGIPTI LEEEDSIETA SLGATTTDSI GLSDTSSEDS 660
  661 HYGNAKKVT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ATO3 FPS1 ITR1 ITR2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FPS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..228] deduced N/A No confident structure predictions are available.
    2 View Details [229..404] PSI-BLAST 308.68867 Glycerol uptake facilitator protein GlpF
    3 View Details [405..557] PSI-BLAST 308.68867 Glycerol uptake facilitator protein GlpF
    4 View Details [558..669] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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