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Protein Overview: ITR2

General Information:
Name(s) found: ITR2 / YOL103W [SGD]
Description(s) found:
Found 17 descriptions.
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  • Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 609 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: myo-inositol transport [IMPLink to PubMed article]
    Molecular Function: myo-inositol transmembrane transporter activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNSTAASSR WTKSRLSHFF PSYTNSSGMG AASTDQSSTQ GEELHHRKHC EEDNDGQKPK  60
   61 KSPVSTSTMQ IKSRQDEDED DGRIVIKPVN DEDDTSVIIT FNQSISPFII TLTFVASISG 120
  121 FMFGYDTGYI SSALISINRD LDNKVLTYGE KELITAATSL GALITSVGAG TAADVFGRRP 180
  181 CLMFSNLMFL IGAILQITAH KFWQMAAGRL IMGFGVGIGS LISPLFISEI APKMIRGRLT 240
  241 VINSLWLTGG QLIAYGCGAG LNHVKNGWRI LVGLSLIPTV LQFSFFCFLP DTPRYYVMKG 300
  301 DLKRAKMVLK RSYVNTEDEI IDQKVEELSS LNQSIPGKNP ITKFWNMVKE LHTVPSNFRA 360
  361 LIIGCGLQAI QQFTGWNSLM YFSGTIFETV GFKNSSAVSI IVSGTNFVFT LIAFFCIDKI 420
  421 GRRYILLIGL PGMTVALVIC AIAFHFLGIK FNGADAVVAS DGFSSWGIVI IVFIIVYAAF 480
  481 YALGIGTVPW QQSELFPQNV RGVGTSYATA TNWAGSLVIA STFLTMLQNI TPTGTFSFFA 540
  541 GVACLSTIFC YFCYPELSGL ELEEVQTILK DGFNIKASKA LAKKRKQQVA EGAAHHKLKF 600
  601 EPTQEIVES

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) HAL5 ITR2
    View Details Qiu et al. (2008) FPS1 ITR1 ITR2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ITR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] deduced N/A No confident structure predictions are available.
    2 View Details [104..609] PSI-BLAST 36.0 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • glycerol transmembrane transporter activity
    		•  7.11654923455995 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  6.7545566917184 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  6.7545566917184 bayes_pls_golite062009
  • glycerol-3-phosphate transmembrane transporter activity
    		•  5.74077413704789 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • hexose phosphate transmembrane transporter activity
    		•  3.3746965264994 bayes_pls_golite062009
  • glucose-6-phosphate transmembrane transporter activity
    		•  3.3746965264994 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  2.99050613058546 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  2.99050613058546 bayes_pls_golite062009
  • monosaccharide transmembrane transporter activity
    		•  2.63293544825311 bayes_pls_golite062009
  • carbohydrate transmembrane transporter activity
    		•  2.62141276633776 bayes_pls_golite062009
  • sugar transmembrane transporter activity
    		•  2.47557586092261 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • solute:hydrogen symporter activity
    		•  2.10485633822652 bayes_pls_golite062009
  • binding
    		•  1.89539096965643 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • sugar binding
    		•  0.285073104957756 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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