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Protein Overview: AAT1

General Information:
Name(s) found: AAT1 / YKL106W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 451 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Biological Process: asparagine biosynthetic process from oxaloacetate [IC]
    aspartate biosynthetic process [IC]
    aspartate catabolic process [TAS]
    Molecular Function: L-aspartate:2-oxoglutarate aminotransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTRLTNCS LWRPYYTSSL SRVPRAPPDK VLGLSEHFKK VKNVNKIDLT VGIYKDGWGK  60
   61 VTTFPSVAKA QKLIESHLEL NKNLSYLPIT GSKEFQENVM KFLFKESCPQ FGPFYLAHDR 120
  121 ISFVQTLSGT GALAVAAKFL ALFISRDIWI PDPSWANHKN IFQNNGFENI YRYSYYKDGQ 180
  181 IDIDGWIEQL KTFAYNNQQE NNKNPPCIIL HACCHNPTGL DPTKEQWEKI IDTIYELKMV 240
  241 PIVDMAYQGL ESGNLLKDAY LLRLCLNVNK YPNWSNGIFL CQSFAKNMGL YGERVGSLSV 300
  301 ITPATANNGK FNPLQQKNSL QQNIDSQLKK IVRGMYSSPP GYGSRVVNVV LSDFKLKQQW 360
  361 FKDVDFMVQR LHHVRQEMFD RLGWPDLVNF AQQHGMFYYT RFSPKQVEIL RNNYFVYLTG 420
  421 DGRLSLSGVN DSNVDYLCES LEAVSKMDKL A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AAT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61]
    [368..451]    		 PSI-BLAST 817.927757 Aspartate aminotransferase, AAT
    2 View Details [62..367] PSI-BLAST 817.927757 Aspartate aminotransferase, AAT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  6.52158261185762 bayes_pls_golite062009
  • phosphatidylserine decarboxylase activity
    		•  3.52333113038086 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.46601963907552 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.46601963907552 bayes_pls_golite062009
  • transferase activity
    		•  1.44093490824786 bayes_pls_golite062009
  • glutamate decarboxylase activity
    		•  1.34215658716536 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • 4-aminobutyrate transaminase activity
    		•  1.11017195698597 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977210827616757 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.892872530648552 bayes_pls_golite062009
  • binding
    		•  0.892049641082766 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  0.87264568471543 bayes_pls_golite062009
  • DNA binding
    		•  0.803965264969424 bayes_pls_golite062009
  • N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
    		•  0.753443687983955 bayes_pls_golite062009
  • vitamin binding
    		•  0.66463470119531 bayes_pls_golite062009
  • transcription factor activity
    		•  0.597417107954964 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.50269055590758 bayes_pls_golite062009
  • alanine-glyoxylate transaminase activity
    		•  0.48682493494502 bayes_pls_golite062009
  • hydrolase activity
    		•  0.343938599116946 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • ligase activity
    		•  0.103307018783573 bayes_pls_golite062009
  • aromatic-amino-acid:2-oxoglutarate aminotransferase activity
    		•  0.0916183433120769 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.0833010353195099 bayes_pls_golite062009
  • amine binding
    		•  0.00719250700539997 bayes_pls_golite062009
  • kynureninase activity
    		•  0.0041576792340694 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle