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View Structure Prediction Details

Protein: AAT1
Organism: Saccharomyces cerevisiae
Length: 451 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AAT1.

Description E-value Query
Range		 Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [9..446] [22..433]
AATM_MOUSE - Aspartate aminotransferase, mitochondrial OS=Mus musculus GN=Got2 PE=1 SV=1
 0.0 [9..446] [22..430]
AATM_RAT - Aspartate aminotransferase, mitochondrial OS=Rattus norvegicus GN=Got2 PE=1 SV=2
 0.0 [9..446] [22..430]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 0.0 [17..446] [1..401]
gi|123981960, gi... - gi|123996785|gb|ABM85994.1| glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotrans...
gi|12653507 - gi|12653507|gb|AAH00525.1| Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransf...
 0.0 [9..446] [22..430]
AATM_HORSE - Aspartate aminotransferase, mitochondrial OS=Equus caballus GN=GOT2 PE=1 SV=1
 0.0 [17..446] [1..401]
gi|7576444 - gi|7576444|dbj|BAA94600.1| 1-aminocyclopropane-1-carboxylate synthase [Populus euramericana]
gi|7576444 - dbj|BAA94600.1| 1-aminocyclopropane-1-carboxylate synthase [Populus euramericana]
 0.0 [16..450] [20..434]
gi|625212 - pir||XNPGDM aspartate transaminase (EC 2.6.1.1) precursor, mitochondrial - pig
AATM_PIG - Aspartate aminotransferase, mitochondrial OS=Sus scrofa GN=GOT2 PE=1 SV=2
 0.0 [9..446] [22..430]

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Predicted Domain #1
Region A:
Residues: [1-61] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTRLTNCS LWRPYYTSSL SRVPRAPPDK VLGLSEHFKK VKNVNKIDLT VGIYKDGWGK  60
   61 V

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [368-451] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQRLHHVRQE MFDRLGWPDL VNFAQQHGMF YYTRFSPKQV EILRNNYFVY LTGDGRLSLS  60
   61 GVNDSNVDYL CESLEAVSKM DKLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 817.927757
Match: 1yaaA_
Description: Aspartate aminotransferase, AAT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
L-aspartate:2-oxoglutarate aminotransferase activity 6.52158261185762 bayes_pls_golite062009
phosphatidylserine decarboxylase activity 3.52333113038086 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 1.46601963907552 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 1.46601963907552 bayes_pls_golite062009
transferase activity 1.44093490824786 bayes_pls_golite062009
glutamate decarboxylase activity 1.34215658716536 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
4-aminobutyrate transaminase activity 1.11017195698597 bayes_pls_golite062009
transcription regulator activity 0.977210827616757 bayes_pls_golite062009
nucleic acid binding 0.892872530648552 bayes_pls_golite062009
binding 0.892049641082766 bayes_pls_golite062009
N-succinyltransferase activity 0.87264568471543 bayes_pls_golite062009
DNA binding 0.803965264969424 bayes_pls_golite062009
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity 0.753443687983955 bayes_pls_golite062009
vitamin binding 0.66463470119531 bayes_pls_golite062009
transcription factor activity 0.597417107954964 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.50269055590758 bayes_pls_golite062009
alanine-glyoxylate transaminase activity 0.48682493494502 bayes_pls_golite062009
hydrolase activity 0.343938599116946 bayes_pls_golite062009
vitamin B6 binding 0.16957228630576 bayes_pls_golite062009
pyridoxal phosphate binding 0.16957228630576 bayes_pls_golite062009
ligase activity 0.103307018783573 bayes_pls_golite062009
aromatic-amino-acid:2-oxoglutarate aminotransferase activity 0.0916183433120769 bayes_pls_golite062009
cystathionine beta-lyase activity 0.0833010353195099 bayes_pls_golite062009
amine binding 0.00719250700539997 bayes_pls_golite062009
kynureninase activity 0.0041576792340694 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [62-367] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTFPSVAKAQ KLIESHLELN KNLSYLPITG SKEFQENVMK FLFKESCPQF GPFYLAHDRI  60
   61 SFVQTLSGTG ALAVAAKFLA LFISRDIWIP DPSWANHKNI FQNNGFENIY RYSYYKDGQI 120
  121 DIDGWIEQLK TFAYNNQQEN NKNPPCIILH ACCHNPTGLD PTKEQWEKII DTIYELKMVP 180
  181 IVDMAYQGLE SGNLLKDAYL LRLCLNVNKY PNWSNGIFLC QSFAKNMGLY GERVGSLSVI 240
  241 TPATANNGKF NPLQQKNSLQ QNIDSQLKKI VRGMYSSPPG YGSRVVNVVL SDFKLKQQWF 300
  301 KDVDFM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 817.927757
Match: 1yaaA_
Description: Aspartate aminotransferase, AAT
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle