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Protein Overview: YKL091C

General Information:
Name(s) found: YKL091C [SGD]
Description(s) found:
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  • gi|6322759|ref|NP_012832.1| Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; Ykl091cp [Saccharomyces cerevisiae] [NCBI NR]
  • gi|549705|sp|P33324.2|YKJ1_YEAST RecName: Full=CRAL-TRIO domain-containing protein YKL091C [NCBI NR]
  • pir||S37916 SEC14 protein homolog YKL091c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486137|emb|CAA81929.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • CRAL-TRIO domain-containing protein YKL091C OS=Saccharomyces cerevisiae GN=YKL091C PE=1 SV=2 [Swiss-Prot]
  • Protein of unknown function localised to cytoplasm and nucleus [mips]
  • Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus [SGD]
  • YKL091C, Chr XI from 269360-270292, reverse complement [yeast_orfs2]
  • Chr XI from 269360-270292, reverse complement [yeastorf3.fasta]
  • Chr XI from 269359-270291, reverse complement [yeastorf4.fasta]
  • Chr XI from 270291-269359, reverse complement [yeastorf5.fasta]
  • (P33324) 36.1 kDa protein in BUD2-MIF2 intergenic region [4932.FASTACCERV.txt]
  • YKL091C SGDID:S0001574, Chr XI from 270295-269363, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • Sec14p homolog [Saccharomyces cerevisiae]gi|486137|emb|CAA81929.1| unnamed protein product [Saccharomyces cerevisiae]gi|549705|sp|P33324|YKJ1_YEAST 36.1 kDa protein in BUD2-MIF2 intergenic regiongi|538623|pir||S37916 SEC14 protein homolog YKL091c - yea [nrdb_11152004_Chlamydomonas]
  • YKL091C SGDID:S000001574, Chr XI from 270294-269362, reverse complement, Verified ORF, "Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; Ykl091cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Uncharacterized protein YKL091C [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • CRAL-TRIO domain-containing protein YKL091C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YKL091C PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • YKL091C SGDID:S000001574, Chr XI from 270650-269718, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study" [yeast-030211-contam.fasta]
  • YKL091C SGDID:S000001574, Chr XI from 270650-269718, Genome Release 64-2-1, reverse complement, Verified ORF, "Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 310 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSILDTYP QICSPNALPG TPGNLTKEQE EALLQFRSIL LEKNYKERLD DSTLLRFLRA  60
   61 RKFDINASVE MFVETERWRE EYGANTIIED YENNKEAEDK ERIKLAKMYP QYYHHVDKDG 120
  121 RPLYFEELGG INLKKMYKIT TEKQMLRNLV KEYELFATYR VPACSRRAGY LIETSCTVLD 180
  181 LKGISLSNAY HVLSYIKDVA DISQNYYPER MGKFYIIHSP FGFSTMFKMV KPFLDPVTVS 240
  241 KIFILGSSYK KELLKQIPIE NLPVKYGGTS VLHNPNDKFY YSDIGPWRDP RYIGPEGEIP 300
  301 NIFGKFTVTS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BSP1 PTC7 SEC14 YKL091C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data YKL091C Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..15]
    [77..310]    		 PSI-BLAST 1189.522879 N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p
    2 View Details [16..76] PSI-BLAST 1189.522879 N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phospholipid transporter activity
    		•  4.82372291869245 bayes_pls_golite062009
  • lipid transporter activity
    		•  3.98714900064429 bayes_pls_golite062009
  • phosphatidylinositol transporter activity
    		•  3.08477039249457 bayes_pls_golite062009
  • transporter activity
    		•  2.25865143268098 bayes_pls_golite062009
  • binding
    		•  2.07034659478808 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.84980732779905 bayes_pls_golite062009
  • retinoid binding
    		•  1.4508809653482 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.32450443851017 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.14391953556505 bayes_pls_golite062009
  • vitamin binding
    		•  0.87942237566918 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.418179505285201 bayes_pls_golite062009
  • protein binding
    		•  0.408110742195811 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.265815679858875 bayes_pls_golite062009
  • protein transporter activity
    		•  0.0570899657188049 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle