YRC Public Data Repository - Protein Structure Prediction

Protein:	YKL091C
Organism:	Saccharomyces cerevisiae
Length:	310 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YKL091C.

Description	E-value	Query Range	Subject Range
YKL091C - Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein inv... YKJ1_YEAST - CRAL-TRIO domain-containing protein YKL091C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...	6.0E-86	[1..310]	[1..310]
SFH3_ARATH - Phosphatidylinositol/phosphatidylcholine transfer protein SFH3 OS=Arabidopsis thaliana GN=SFH3 PE=2 ...	4.0E-80	[10..301]	[49..341]
SEC14_KLULA - SEC14 cytosolic factor OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 ... SEC14_KLULA, SC1... - SEC14 cytosolic factor OS=Kluyveromyces lactis GN=SEC14 PE=3 SV=2, (P24859) SEC14 cytosolic factor (...	4.0E-80	[3..303]	[5..299]
gi\|14517816 - gi\|14517816\|gb\|AAK64378.1\|AF366901_1 phosphatidylinositol transfer-like protein II [Lotus japonicus]	1.0E-78	[4..301]	[29..327]
SEC14_CANGA - SEC14 cytosolic factor OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL... SEC14_CANGA, SC1... - SEC14 cytosolic factor OS=Candida glabrata GN=SEC14 PE=3 SV=1, (P53989) SEC14 cytosolic factor (Phos...	4.0E-78	[4..303]	[6..299]

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Predicted Domain #1

Region A:
Residues: [1-15]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSILDTYP QICSP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [77-310]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RWREEYGANT IIEDYENNKE AEDKERIKLA KMYPQYYHHV DKDGRPLYFE ELGGINLKKM  60
   61 YKITTEKQML RNLVKEYELF ATYRVPACSR RAGYLIETSC TVLDLKGISL SNAYHVLSYI 120
  121 KDVADISQNY YPERMGKFYI IHSPFGFSTM FKMVKPFLDP VTVSKIFILG SSYKKELLKQ 180
  181 IPIENLPVKY GGTSVLHNPN DKFYYSDIGP WRDPRYIGPE GEIPNIFGKF TVTS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1189.522879
Match:	1aua__
Description:	N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phospholipid transporter activity	4.82372291869245	bayes_pls_golite062009
lipid transporter activity	3.98714900064429	bayes_pls_golite062009
phosphatidylinositol transporter activity	3.08477039249457	bayes_pls_golite062009
transporter activity	2.25865143268098	bayes_pls_golite062009
binding	2.07034659478808	bayes_pls_golite062009
substrate-specific transporter activity	1.84980732779905	bayes_pls_golite062009
retinoid binding	1.4508809653482	bayes_pls_golite062009
isoprenoid binding	1.32450443851017	bayes_pls_golite062009
transmembrane transporter activity	1.14391953556505	bayes_pls_golite062009
vitamin binding	0.87942237566918	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.418179505285201	bayes_pls_golite062009
protein binding	0.408110742195811	bayes_pls_golite062009
transcription regulator activity	0.265815679858875	bayes_pls_golite062009
protein transporter activity	0.0570899657188049	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [16-76]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NALPGTPGNL TKEQEEALLQ FRSILLEKNY KERLDDSTLL RFLRARKFDI NASVEMFVET  60
   61 E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1189.522879
Match:	1aua__
Description:	N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: