Protein Overview: MSN4

General Information:
Name(s) found:	MSN4 / YKL062W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322788\|ref\|NP_012861.1\| Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; [NCBI NR] pir\|\|S37884 finger protein MSN4 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|486083\|emb\|CAA81899.1\| MSN4 [Saccharomyces cerevisiae] [NCBI NR] gi\|462626\|sp\|P33749.1\|MSN4_YEAST RecName: Full=Zinc finger protein MSN4; AltName: Full=Multicopy suppressor of SNF1 protein 4 [NCBI NR] gi\|433646\|emb\|CAA53421.1\| C630; human transcription factor homologue [Saccharomyces cerevisiae] [NCBI NR] gi\|349593\|gb\|AAA34807.1\| zinc finger protein [NCBI NR] gi\|1587555\|prf\|\|2206495D ORF [NCBI NR] Zinc finger protein MSN4 OS=Saccharomyces cerevisiae GN=MSN4 PE=1 SV=1 [Swiss-Prot] MSN4 Transcriptional activator [mips] Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression [SGD] MSN4, Chr XI from 322870-324762 [yeast_orfs2] Chr XI from 322870-324762 [yeastorf3.fasta] Chr XI from 322869-324761 [yeastorf4.fasta] (P33749) Zinc finger protein MSN4 (Multicopy suppressor of SNF1 protein 4) [4932.FASTACCERV.txt] MSN4 SGDID:S0001545, Chr XI from 322873-324765, Verified ORF [yeastflysequest.fasta] Msn4p [Saccharomyces cerevisiae]gi\|433646\|emb\|CAA53421.1\| C630; human transcription factor homologue [Saccharomyces cerevisiae]gi\|486083\|emb\|CAA81899.1\| MSN4 [Saccharomyces cerevisiae]gi\|462626\|sp\|P33749\|MSN4_YEAST Zinc finger protein MSN4 (Multicopy s [nrdb_11152004_Chlamydomonas] MSN4 SGDID:S000001545, Chr XI from 322872-324764, Verified ORF, "Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of respons [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] zinc finger protein [nr-271106-contam.fasta] MSN4 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Zinc finger protein MSN4 (Multicopy suppressor of SNF1 protein 4) [nr-271106-contam.fasta] Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; Msn4p [Saccharomyces cerevis [nr-271106-contam.fasta] C630; human transcription factor homologue [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ORF [nr-271106-contam.fasta] MSN4 SGDID:S000001545, Chr XI from 322872-324764, Verified ORF, "Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Zinc finger protein MSN4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSN4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MSN4 SGDID:S000001545, Chr XI from 323228-325120, Genome Release 64-1-1, Verified ORF, "Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression" [yeast-030211-contam.fasta] MSN4 SGDID:S000001545, Chr XI from 323228-325120, Genome Release 64-2-1, Verified ORF, "Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift" [20141208_orf_trans.fasta] YKL062W SGDID:S000001545, Chr XI from 323228-325120, Genome Release 64-1-1, Verified ORF, "Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	630 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	response to oxidative stress [IGI] response to hydrostatic pressure [IGI] heat acclimation [IMP] regulation of transcription from RNA polymerase II promoter in response to stress [IMP] response to osmotic stress [IGI] response to freezing [IGI] replicative cell aging [IMP] age-dependent response to oxidative stress involved in chronological cell aging [IMP] response to stress [IMP] cellular response to glucose starvation [IMP]
Molecular Function:	transcription factor activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVFGPNSSF VRHANKKQED SSIMNEPNGL MDPVLSTTNV SATSSNDNSA NNSISSPEYT  60
   61 FGQFSMDSPH RTDATNTPIL TATTNTTANN SLMNLKDTAS LATNWKWKNS NNAQFVNDGE 120
  121 KQSSNANGKK NGGDKIYSSV ATPQALNDEL KNLEQLEKVF SPMNPINDSH FNENIELSPH 180
  181 QHATSPKTNL LEAEPSIYSN LFLDARLPNN ANSTTGLNDN DYNLDDTNND NTNSMQSILE 240
  241 DFVSSEEALK FMPDAGRDAR RYSEVVTSSF PSMTDSRNSI SHSIEFWNLN HKNSSNSKPT 300
  301 QQIIPEGTAT TERRGSTISP TTTINNSNPN FKLLDHDVSQ ALSGYSMDFS KDSGITKPKS 360
  361 ISSSLNRISH SSSTTRQQRA SLPLIHDIES FANDSVMANP LSDSASFLSE ENEDDAFGAL 420
  421 NYNSLDATTM SAFDNNVDPF NILKSSPAQD QQFIKPSMML SDNASAAAKL ATSGVDNITP 480
  481 TPAFQRRSYD ISMNSSFKIL PTSQAHHAAQ HHQQQPTKQA TVSPNTRRRK SSSVTLSPTI 540
  541 SHNNNNGKVP VQPRKRKSIT TIDPNNYDKN KPFKCKDCEK AFRRSEHLKR HIRSVHSTER 600
  601 PFACMFCEKK FSRSDNLSQH LKTHKKHGDF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		GET2 GET3 MSN4

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	HBT1	MSN4	1	Unpublished Fields Lab Data
View Screen	CAB2	MSN4	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..212]	MSA	4.390995	View MSA. No confident structure predictions are available.
2	View Details	[213..349]	MSA	20.919997	View MSA. No confident structure predictions are available.
3	View Details	[350..460]	PSI-BLAST	32.218487	Transcription factor IIIA, TFIIIA
4	View Details	[461..557]	PSI-BLAST	128.09691	ZIF268
5	View Details	[558..630]	PSI-BLAST	130.30103	ZIF268

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2