Protein Overview: PAN3

General Information:
Name(s) found:	PAN3 / YKL025C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322827\|ref\|NP_012900.1\| Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; Pan3p [Saccharomyces cerevisiae] [NCBI NR] gi\|549662\|sp\|P36102.1\|PAN3_YEAST RecName: Full=PAB-dependent poly(A)-specific ribonuclease subunit PAN3; AltName: Full=PAB1P-dependent poly(A)-nuclease [NCBI NR] pir\|\|S37842 hypothetical protein YKL025c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|486021\|emb\|CAA81860.1\| PAN3 [Saccharomyces cerevisiae] [NCBI NR] PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Saccharomyces cerevisiae GN=PAN3 PE=1 SV=1 [Swiss-Prot] PAN3 Component of the Pab1p-dependent poly(A) ribonuclease [mips] Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes [SGD] PAN3, Chr XI from 389878-391917, reverse complement [yeast_orfs2] Chr XI from 389878-391917, reverse complement [yeastorf3.fasta] Chr XI from 391917-389878, reverse complement [yeastorf5.fasta] (P36102) PAB-dependent poly(A)-specific ribonuclease subunit PAN3 (EC 3.1.13.4) (PAB1P-dependent poly(A)-nuclease) [4932.FASTACCERV.txt] PAN3 SGDID:S0001508, Chr XI from 391922-389883, reverse complement, Verified ORF [yeastflysequest.fasta] Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes [Saccharomyces cerevisiae]gi\|486021\|emb\|CAA81860.1\| PAN3 [Sacchar [nrdb_11152004_Chlamydomonas] PAN3 SGDID:S000001508, Chr XI from 391922-389883, reverse complement, Verified ORF, "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplicatio [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; Pan3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] PAB-dependent poly(A)-specific ribonuclease subunit PAN3 (PAB1P-dependent poly(A)-nuclease) [nr-271106-contam.fasta] PAN3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] PAN3 SGDID:S000001508, Chr XI from 391922-389883, reverse complement, Verified ORF, "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes" [yeast-bovrabprots.fasta] [chemostatdb.fasta] PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PAN3 SGDID:S000001508, Chr XI from 392279-390240, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes" [yeast-030211-contam.fasta] PAN3 SGDID:S000001508, Chr XI from 392279-390240, Genome Release 64-2-1, reverse complement, Verified ORF, "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regulates the stoichiometry and activity of postreplication repair complexes" [20141208_orf_trans.fasta] YKL025C SGDID:S000001508, Chr XI from 392279-390240, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] PAN2-PAN3 deadenylation complex subunit PAN3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN3 PE=1 SV=1 [Swanson-Carlisle-Scereplusabalone-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	679 amino acids
Gene Ontology:
Cellular Component:	PAN complex [IDA] cytoplasm [IDA]
Biological Process:	DNA repair [IDA] mRNA 3'-end processing [IMP][IPI] postreplication repair [IGI][IPI]
Molecular Function:	poly(A)-specific ribonuclease activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKINPDWAK DIPCRNITIY GYCKKEKEGC PFKHSDNTTA TTINDVPPPI DVGEATTPTM  60
   61 TSVPKFNAKV SASFTPMTVG SDSLTTVTNT TSAATNATGN IAMAATSATA STVNPMINPI 120
  121 VNSSLVNNNN NNSNISISIP TTASSSNYDP FNAPIFTPSS TSSIHTNANA HSFPFPSIAN 180
  181 SGGININATD DNSNNMSMAN NVPPPMQPPP IESSNLKYPR IYPPPHSLLQ YHLYAPEQPS 240
  241 SLKSLLKPNE RSADQLFIPN NIREDLTKKN LSILQVFPSS GKVIPSIVQD YFNLVPLNFN 300
  301 NNDFLNKTTL FKVFSNYDGK AYVLKRLPNI DKSMNPNKIS KIYQIWSKIN CTNLIKFRDI 360
  361 FQTTKFGDLS ICLVFDYYPN SLSLYDYHFV NFPKFPITNN YLWIYLVQLT NVINSIHSQN 420
  421 LSIGNTLNWR KVLITGDPGR IKLSHCNFMD LLFNDDTDTV VSSGGSTIEG QQQLDYKYLG 480
  481 ELLFNLSINI ENSNNNTAPK EYRLEEITPQ SIDDMRQIDD KFKDVLKYLI SDNGDSKKSI 540
  541 HDLTSHFYDK MFMVLESSQT YTEYMESVLS RELENGRLFR LVNKLNCIFG RIESRIDINW 600
  601 SESGTKFPII LFYDYVFHQV DSNGKPIMDL THVLRCLNKL DAGIQEKLML VTPDELNCII 660
  661 ISYKELKDLI ESTFRSITQ

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		PAN2 PAN3
View Details	Krogan NJ, et al. (2006)		PAN2 PAN3
View Details	Gavin AC, et al. (2006)		PAN2 PAN3
View Details	Gavin AC, et al. (2002)		PAN2 PAN3
View Details	Qiu et al. (2008)		PAN2 PAN3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD51	PAN3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PAN3	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..224]	deduced	N/A	No confident structure predictions are available.
2	View Details	[225..382] [567..585]	PSI-BLAST	82.221849	Calmodulin-dependent protein kinase
3	View Details	[383..566]	PSI-BLAST	82.221849	Calmodulin-dependent protein kinase
4	View Details	[586..679]	PSI-BLAST	5.30103	Troponin C

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2