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Protein Overview: NIT2

General Information:
Name(s) found: NIT2 / YJL126W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 307 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKLKRVAV AQLCSSADLT KNLKVVKELI SEAIQKKADV VFLPEASDYL SQNPLHSRYL  60
   61 AQKSPKFIRQ LQSSITDLVR DNSRNIDVSI GVHLPPSEQD LLEGNDRVRN VLLYIDHEGK 120
  121 ILQEYQKLHL FDVDVPNGPI LKESKSVQPG KAIPDIIESP LGKLGSAICY DIRFPEFSLK 180
  181 LRSMGAEILC FPSAFTIKTG EAHWELLGRA RAVDTQCYVL MPGQVGMHDL SDPEWEKQSH 240
  241 MSALEKSSRR ESWGHSMVID PWGKIIAHAD PSTVGPQLIL ADLDRELLQE IRNKMPLWNQ 300
  301 RRDDLFH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NIT2 TUP1 2 Unpublished Fields Lab Data
    View Screen NIT2 HTZ1 2 Unpublished Fields Lab Data
    View Screen NIT2 PAA1 2 Unpublished Fields Lab Data
    View Screen NIT2 CBS2 2 Unpublished Fields Lab Data
    View Screen NIT2 MZM1 2 Unpublished Fields Lab Data
    View Screen NIT2 ABP140 2 Unpublished Fields Lab Data
    View Screen NIT2 SMA1 2 Unpublished Fields Lab Data
    View Screen NIT2 YIR014W 2 Unpublished Fields Lab Data
    View Screen NIT2 YKL115C 1 Unpublished Fields Lab Data
    View Screen NIT2 MLC2 1 Unpublished Fields Lab Data
    View Screen NIT2 SRL3 1 Unpublished Fields Lab Data
    View Screen NIT2 HRT3 1 Unpublished Fields Lab Data
    View Screen NIT2 YLR269C 1 Unpublished Fields Lab Data
    View Screen SNF1 NIT2 1 Unpublished Fields Lab Data
    View Screen NIT2 SFH1 1 Unpublished Fields Lab Data
    View Screen NIT2 SHE3 1 Unpublished Fields Lab Data
    View Screen NIT2 ARC18 1 Unpublished Fields Lab Data
    View Screen NIT2 PGS1 1 Unpublished Fields Lab Data
    View Screen NIT2 CEP3 1 Unpublished Fields Lab Data
    View Screen NIT2 TAT2 1 Unpublished Fields Lab Data
    View Screen NIT2 TAF10 1 Unpublished Fields Lab Data
    View Screen NIT2 RPB2 1 Unpublished Fields Lab Data
    View Screen NIT2 RPS28A 1 Unpublished Fields Lab Data
    View Screen NIT2 RPS23B, RPS23A 1 Unpublished Fields Lab Data
    View Screen NIT2 OSW1 1 Unpublished Fields Lab Data
    View Screen NIT2 ARG4 1 Unpublished Fields Lab Data
    View Screen NIT2 KAR9 1 Unpublished Fields Lab Data
    View Screen NIT2 OPI3 1 Unpublished Fields Lab Data
    View Screen NIT2 SUA7 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..307] PSI-BLAST 552.522879 NIT-FHIT fusion protein, C-terminal domain; NIT-FHIT fusion protein, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.64442398754697 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.35962310800332 bayes_pls_golite062009
  • N-carbamoylputrescine amidase activity
    		•  0.749539597459006 bayes_pls_golite062009
  • hydrolase activity
    		•  0.06604196264626 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle