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Protein Overview: QDR2

General Information:
Name(s) found: QDR2 / YIL121W [SGD]
Description(s) found:
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  • gi|731865|sp|P40474.1|YIM1_YEAST RecName: Full=Uncharacterized transporter YIL121W [NCBI NR]
  • gi|6322070|ref|NP_012145.1| Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake; Qdr2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|599996|emb|CAA86871.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51012921|gb|AAT92754.1| YIL121W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S49888 probable membrane protein YIL121w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Uncharacterized transporter YIL121W OS=Saccharomyces cerevisiae GN=YIL121W PE=1 SV=1 [Swiss-Prot]
  • Quinidine resistance protein 2 OS=Saccharomyces cerevisiae GN=QDR2 PE=1 SV=1 [Swiss-Prot]
  • QDR2 Multidrug transporter, function as a quinidine resistance determinant [mips]
  • Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake [SGD]
  • YIL121W, Chr IX from 132241-133869 [yeast_orfs2]
  • Chr IX from 132241-133869 [yeastorf3.fasta]
  • (P40474) Hypothetical 59.6 kDa protein in KGD1-SIM1 intergenic region [4932.FASTACCERV.txt]
  • QDR2 SGDID:S0001383, Chr IX from 132241-133869, Uncharacterized ORF [yeastflysequest.fasta]
  • QDR2 SGDID:S0001383, Chr IX from 132241-133869, Verified ORF [10112005cervSGD.fasta]
  • Multidrug transporter responsible for resistance to quinidine and barban; member of a family of drug:proton antiporters; plasma membrane transporter [Saccharomyces cerevisiae]gi|51012921|gb|AAT92754.1| YIL121W [Saccharomyces cerevisiae]gi|599996|emb|CAA [nrdb_11152004_Chlamydomonas]
  • QDR2 SGDID:S000001383, Chr IX from 132241-133869, Verified ORF, "Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; member of the major facilitator superfamily of transporters conferring multiple drug resistance [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • QDR2 SGDID:S000001383, Chr IX from 132241-133869, Verified ORF, "Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • YIL121W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR); Qdr2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Uncharacterized transporter YIL121W [nr-271106-contam.fasta]
  • QDR2 SGDID:S000001383, Chr IX from 132241-133869, Verified ORF, "Multidrug transporter required for resistance to quinidine, barban, cisplatin, and bleomycin; member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR)" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Quinidine resistance protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=QDR2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • QDR2 SGDID:S000001383, Chr IX from 132244-133872, Genome Release 64-1-1, Verified ORF, "Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake" [yeast-030211-contam.fasta]
  • QDR2 SGDID:S000001383, Chr IX from 132244-133872, Genome Release 64-2-1, Verified ORF, "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper" [20141208_orf_trans.fasta]
  • YIL121W SGDID:S000001383, Chr IX from 132244-133872, Genome Release 64-1-1, Verified ORF, "Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 542 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDALink to PubMed article]
    Biological Process: drug transmembrane transport [IMPLink to PubMed article]
    potassium ion import [IMPLink to PubMed article]
    Molecular Function: substrate-specific transmembrane transporter activity [RCA]
    drug transmembrane transporter activity [IMP]
    transporter activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGATSSIIR ENDFEDELAE SMQSYNRETA DKLALTRTES VKPEPEITAP PHSRFSRSFK  60
   61 TVLIAQCAFT GFFSTIAGAI YYPVLSVIER KFDIDEELVN VTVVVYFVFQ GLAPTFMGGF 120
  121 ADSLGRRPVV LVAIVIYFGA CIGLACAQTY AQIIVLRCLQ AAGISPVIAI NSGIMGDVTT 180
  181 RAERGGYVGY VAGFQVLGSA FGALIGAGLS SRWGWRAIFW FLAIGSGICF LASFLILPET 240
  241 KRNISGNGSV TPKSYLNRAP ILVLPTVRKS LHLDNPDYET LELPTQLNLL APFKILKAYE 300
  301 ICILMLVAGL QFAMYTTHLT ALSTALSKQY HLTVAKVGLC YLPSGICTLC SIVIAGRYLN 360
  361 WNYRRRLKYY QNWLGKKRSK LLEEHDNDLN LVQRIIENDP KYTFNIFKAR LQPAFVTLLL 420
  421 SSSGFCAYGW CITVKAPLAA VLCMSGFASL FSNCILTFST TLIVDLFPTK TSTATGCLNL 480
  481 FRCILSAVFI AALSKMVEKM KFGGVFTFLG ALTSSSSILL FILLRKGKEL AFKRKKQELG 540
  541 VN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ASF1 HIR1 HIR2 HIR3 HPC2 QDR2 SFP1
    View Details Qiu et al. (2008) ATR1 PDR5 QDR1 QDR2 QDR3 SGE1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data QDR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..469] PSI-BLAST 17.045757 No description for 1lviA_ was found.
    2 View Details [470..542] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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