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Protein Overview: MTG2

General Information:
Name(s) found: MTG2 / YHR168W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 499 amino acids

    Gene Ontology:
    Cellular Component: extrinsic to membrane [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: translation [IMPLink to PubMed article]
    Molecular Function: GTPase activity [ISSLink to PubMed article]
    ribosome binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIAWSSVFK RELRLERFLP RVYSTKVPDN APRAADNEQW LETLRPITHP EQKKSDHDVS  60
   61 YTRHINVPLG EVTSVNYLQR YNKHKHSQGN FVDVRIVKCK SGAGGSGAVS FFRDAGRSIG 120
  121 PPDGGDGGAG GSVYIQAVAG LGSLAKMKTT YTAEDGEAGA ARQLDGMRGR DVLIQVPVGT 180
  181 VVKWCLPPQK VRELVEREMR KDNNATLRSI LGSTAVNLSV SSGSHRKKIQ LYRHEMAESW 240
  241 LFKDKAKEYH ENKDWFKDLH KKMEAYDHSL EQSELFNDQF PLAGLDLNQP MTKPVCLLKG 300
  301 GQGGLGNMHF LTNLIRNPRF SKPGRNGLEQ HFLFELKSIA DLGLIGLPNA GKSTILNKIS 360
  361 NAKPKIGHWQ FTTLSPTIGT VSLGFGQDVF TVADIPGIIQ GASLDKGMGL EFLRHIERSN 420
  421 GWVFVLDLSN KNPLNDLQLL IEEVGTLEKV KTKNILIVCN KVDIDAEKSE SFAKYLQVEK 480
  481 FSKSQEWDCV PISALREKT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..324] Pfam 108.29243 GTP1/OBG No confident structure predictions are available.
    2 View Details [325..499] PSI-BLAST 62.69897 ADP-ribosylation factor
    3 View Details [128..184] PSI-BLAST 13.045757 Structure of the GTP-binding protein TrmE from Thermotoga maritima
    4 View Details [185..499] PSI-BLAST 64.0 Obg GTP-binding protein N-terminal domain; Obg GTP-binding protein C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • catalytic activity
    		•  1.65079399897053 bayes_pls_golite062009
  • binding
    		•  0.604868700215668 bayes_pls_golite062009
  • aminomethyltransferase activity
    		•  0.573831999310668 bayes_pls_golite062009
  • transferase activity
    		•  0.217873555384951 bayes_pls_golite062009
    4
    Term Confidence Notes
  • binding
    		•  1.62320027057768 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.913322399315129 bayes_pls_golite062009
  • GTPase activity
    		•  0.87408935068982 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.738234102557832 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.569910969126728 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.568840867400671 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.568779924702229 bayes_pls_golite062009
  • nucleotide binding
    		•  0.564275755355315 bayes_pls_golite062009
  • hydrolase activity
    		•  0.441914529351098 bayes_pls_golite062009
  • DNA binding
    		•  0.376487324624615 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • ATP binding
    		•  0.1860481660648 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.152859582615242 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.150159515184919 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.138615225841109 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0880086189831292 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0746809525189132 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0558641287316701 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0557582578674931 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0529869469040288 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle