Protein Overview: HXT5

General Information:
Name(s) found:	HXT5 / YHR096C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|729781\|sp\|P38695.1\|HXT5_YEAST RecName: Full=Probable glucose transporter HXT5 [NCBI NR] gi\|6321888\|ref\|NP_011964.1\| Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; Hxt5p [Sacch [NCBI NR] pir\|\|S43742 hexose transport protein HXT5 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|487940\|gb\|AAB68934.1\| Hxt5p: Hexose transporter [Saccharomyces cerevisiae] [NCBI NR] gi\|473149\|emb\|CAA54923.1\| hexose transporter [Saccharomyces cerevisiae] [NCBI NR] Probable glucose transporter HXT5 OS=Saccharomyces cerevisiae GN=HXT5 PE=1 SV=1 [Swiss-Prot] HXT5 Hxt family protein with intrinsic hexose transport activity [mips] Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs [SGD] HXT5, Chr VIII from 294671-296449, reverse complement [yeast_orfs2] Chr VIII from 294671-296449, reverse complement [yeastorf3.fasta] Chr VIII from 296449-294671, reverse complement [yeastorf5.fasta] (P38695) Probable glucose transporter HXT5 [4932.FASTACCERV.txt] HXT5 SGDID:S0001138, Chr VIII from 296449-294671, reverse complement, Verified ORF [yeastflysequest.fasta] Hexose transporter with moderate affinity for glucose, may function in accumulation of reserve carbohydrates during stress, expression induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs [Saccharomyces cerev [nrdb_11152004_Chlamydomonas] HXT5 SGDID:S000001138, Chr VIII from 296450-294672, reverse complement, Verified ORF, "Hexose transporter with moderate affinity for glucose, may function in accumulation of reserve carbohydrates during stress, expression induced by a decrease in growth r [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] HXT5 SGDID:S000001138, Chr VIII from 296450-294672, reverse complement, Verified ORF, "Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an exte [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Hexose transporter with moderate affinity for glucose, may function in accumulation of reserve carbohydrates during stress, expression induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; Hxt5p [Saccharomyce [nr-271106-contam.fasta] hexose transporter [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Hxt5p: Hexose transporter [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Probable glucose transporter HXT5 [nr-271106-contam.fasta] HXT5 SGDID:S000001138, Chr VIII from 296450-294672, reverse complement, Verified ORF, "Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs" [yeast-bovrabprots.fasta] HXT5 SGDID:S000001138, Chr VIII from 296450-294672, reverse complement, Verified ORF, "Hexose transporter with moderate affinity for glucose, may function in accumulation of reserve carbohydrates during stress, expression induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs" [yeast-contam_custom.fasta] [chemostatdb.fasta] Probable glucose transporter HXT5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HXT5 SGDID:S000001138, Chr VIII from 296447-294669, Genome Release 64-1-1, reverse complement, Verified ORF, "Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs" [yeast-030211-contam.fasta] HXT5 SGDID:S000001138, Chr VIII from 296447-294669, Genome Release 64-2-1, reverse complement, Verified ORF, "Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YHR096C SGDID:S000001138, Chr VIII from 296447-294669, Genome Release 64-1-1, reverse complement, Verified ORF, "Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	592 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [ISS]
Biological Process:	hexose transport [IGI]
Molecular Function:	fructose transmembrane transporter activity [IGI] glucose transmembrane transporter activity [IDA][IGI] mannose transmembrane transporter activity [IGI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELENAHQG PLEGSATVST NSNSYNEKSG NSTAPGTAGY NDNLAQAKPV SSYISHEGPP  60
   61 KDELEELQKE VDKQLEKKSK SDLLFVSVCC LMVAFGGFVF GWDTGTISGF VRQTDFIRRF 120
  121 GSTRANGTTY LSDVRTGLMV SIFNIGCAIG GIVLSKLGDM YGRKIGLMTV VVIYSIGIII 180
  181 QIASIDKWYQ YFIGRIISGL GVGGITVLAP MLISEVSPKQ LRGTLVSCYQ LMITFGIFLG 240
  241 YCTNFGTKNY SNSVQWRVPL GLCFAWSIFM IVGMTFVPES PRYLVEVGKI EEAKRSLARA 300
  301 NKTTEDSPLV TLEMENYQSS IEAERLAGSA SWGELVTGKP QMFRRTLMGM MIQSLQQLTG 360
  361 DNYFFYYGTT IFQAVGLEDS FETAIVLGVV NFVSTFFSLY TVDRFGRRNC LLWGCVGMIC 420
  421 CYVVYASVGV TRLWPNGQDQ PSSKGAGNCM IVFACFYIFC FATTWAPVAY VLISESYPLR 480
  481 VRGKAMSIAS ACNWIWGFLI SFFTPFITSA INFYYGYVFM GCMVFAYFYV FFFVPETKGL 540
  541 TLEEVNEMYE ENVLPWKSTK WIPPSRRTTD YDLDATRNDP RPFYKRMFTK EK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ATP3 HXT5 SAP155 SAP190 SIT4 TAP42
View Details	Qiu et al. (2008)		HXT10 HXT5 HXT8

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	HXT5	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..58]	deduced	N/A	No confident structure predictions are available.
2	View Details	[59..278] [324..538]	PSI-BLAST	476.218487	No description for 1ja5A_ was found.
3	View Details	[279..323] [539..592]	PSI-BLAST	476.218487	No description for 1ja5A_ was found.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
glycerol transmembrane transporter activity	7.11654923455995	bayes_pls_golite062009
alcohol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
polyol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity	5.74077413704789	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	2.63293544825311	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
binding	1.89539096965643	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
sugar binding	0.285073104957756	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2