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Protein Overview: MSR1

General Information:
Name(s) found: MSR1 / YHR091C [SGD]
Description(s) found:
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  • gi|6321883|ref|NP_011959.1| Mitochondrial arginyl-tRNA synthetase; Msr1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S46723 arginine-tRNA ligase (EC 6.1.1.19), mitochondrial - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|487937|gb|AAB68931.1| Msr1p: Arginyl-tRNA synthetase [Saccharomyces cerevisiae] [NCBI NR]
  • MSR1 Arginyl-tRNA synthetase, mitochondrial [mips]
  • Mitochondrial arginyl-tRNA synthetase [SGD]
  • MSR1, Chr VIII from 284840-286771, reverse complement [yeast_orfs2]
  • Chr VIII from 284840-286771, reverse complement [yeastorf3.fasta]
  • Chr VIII from 286771-284840, reverse complement [yeastorf5.fasta]
  • MSR1 SGDID:S0001133, Chr VIII from 286771-284840, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Msr1p [Saccharomyces cerevisiae]gi|487937|gb|AAB68931.1| Msr1p: Arginyl-tRNA synthetase [Saccharomyces cerevisiae]gi|626642|pir||S46723 arginine-tRNA ligase (EC 6.1.1.19), mitochondrial - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • MSR1 SGDID:S000001133, Chr VIII from 286772-284841, reverse complement, Verified ORF, "Mitochondrial arginyl-tRNA synthetase" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Mitochondrial arginyl-tRNA synthetase; Msr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Msr1p: Arginyl-tRNA synthetase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Arginine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSR1 PE=2 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MSR1 SGDID:S000001133, Chr VIII from 286770-284839, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial arginyl-tRNA synthetase" [yeast-030211-contam.fasta]
  • Arginine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSR1 PE=3 SV=3 [YEAST.fasta.20131015]
  • MSR1 SGDID:S000001133, Chr VIII from 286770-284839, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YHR091C SGDID:S000001133, Chr VIII from 286770-284839, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial arginyl-tRNA synthetase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 643 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Biological Process: arginyl-tRNA aminoacylation [IMPLink to PubMed article]
    translation [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: arginine-tRNA ligase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGIVYLKNR SLLCKNPFSS YPRYGFMPSF DTQFSNQFRK LEINIGRKRY SSKTLNTKYT  60
   61 DQPEGPIYPL DVLRLDISKA LHDISGIDHS LILNALESTN SMDRGDLLLP LPKIKVADPV 120
  121 AVANRWAIEL STHGCIGKVC AKGPFLQFFL DQRYLIQSTV PNILLQKGKY GQKKSRHQKK 180
  181 VVVEFSSPNI AKPFHAGHLR STIIGGFLSN LYEAMGWSVT RMNYLGDWGR QFGLLAVGFK 240
  241 RYGDEKTLQK QPIQHLFDVY VKINMDLAKE EINGNSKCGI SGEARSFFKN LENGDENAIK 300
  301 IWNRFRSLSI HHYIQTYSRL NINFDIFSGE SQVSKESMNE ALDIFRKNNL VKEIDGALVI 360
  361 DLTQWSKRLG RVVVQKSDGT TLYLTRDVGA AIERKKNLHF DKMVYVISSQ QDLYMSQFFM 420
  421 ILKKMNFEWA KDLQHINFGM VQGMSTRKGN VVFLDTILDE ARDKALQIME NNKMKISQVD 480
  481 NPQRVADLIG VSAIIIQDMK SKRINNYEFN WNRMLSFEGD TGPYLQYTHS RLRSLERTSS 540
  541 DFTTDMLIHA DFSNLNEPQL VELVRLLAQY PDVLRRAFET QEPATIVTYL FKVCHQVSSC 600
  601 YKKIWVSGKP ADIAIPRLAV YSASRQVLHN AMSLLGLVPV DRM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RGT2 MSR1 1 Unpublished Fields Lab Data
    View Screen FRQ1 MSR1 1 Unpublished Fields Lab Data
    View Screen RAD51 MSR1 1 Unpublished Fields Lab Data
    View Screen UBC6 MSR1 1 Unpublished Fields Lab Data
    View Screen NUP2 MSR1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] PSI-BLAST 10178.0 Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
    2 View Details [152..172]
    [451..643]    		 PSI-BLAST 10178.0 Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
    3 View Details [173..227]
    [308..450]    		 PSI-BLAST 10178.0 Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
    4 View Details [228..307] PSI-BLAST 10178.0 Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.16276509815667 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.16276509815667 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.13957775963187 bayes_pls_golite062009
  • ligase activity
    		•  6.11211476973434 bayes_pls_golite062009
  • arginine-tRNA ligase activity
    		•  5.72854650987135 bayes_pls_golite062009
  • isoleucine-tRNA ligase activity
    		•  3.76808520367507 bayes_pls_golite062009
  • glutamate-tRNA ligase activity
    		•  2.63681738794687 bayes_pls_golite062009
  • methionine-tRNA ligase activity
    		•  2.56893064485672 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • tyrosine-tRNA ligase activity
    		•  1.88984817882585 bayes_pls_golite062009
  • tryptophan-tRNA ligase activity
    		•  1.14187887833901 bayes_pls_golite062009
  • cysteine-tRNA ligase activity
    		•  0.844943947059557 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.625793556381714 bayes_pls_golite062009
  • binding
    		•  0.485102284225571 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.449504767632354 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.2293846471193 bayes_pls_golite062009
  • glutamine-tRNA ligase activity
    		•  0.118292082006187 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle