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Protein Overview: SSZ1

General Information:
Name(s) found: SSZ1 / YHR064C [SGD]
Description(s) found:
Found 10 descriptions.
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  • Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: regulation of translational fidelity [IMPLink to PubMed article]
    translation [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: unfolded protein binding [IGILink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYMVVSSPI QEVLRLHKYI EISTTTITVK ITNKMSSPVI GITFGNTSSS IAYINPKNDV  60
   61 DVIANPDGER AIPSALSYVG EDEYHGGQAL QQLIRNPKNT IINFRDFIGL PFDKCDVSKC 120
  121 ANGAPAVEVD GKVGFVISRG EGKEEKLTVD EVVSRHLNRL KLAAEDYIGS AVKEAVLTVP 180
  181 TNFSEEQKTA LKASAAKIGL QIVQFINEPS AALLAHAEQF PFEKDVNVVV ADFGGIRSDA 240
  241 AVIAVRNGIF TILATAHDLS LGGDNLDTEL VEYFASEFQK KYQANPRKNA RSLAKLKANS 300
  301 SITKKTLSNA TSATISIDSL ADGFDYHASI NRMRYELVAN KVFAQFSSFV DSVIAKAELD 360
  361 PLDIDAVLLT GGVSFTPKLT TNLEYTLPES VEILGPQNKN ASNNPNELAA SGAALQARLI 420
  421 SDYDADELAE ALQPVIVNTP HLKKPIGLIG AKGEFHPVLL AETSFPVQKK LTLKQAKGDF 480
  481 LIGVYEGDHH IEEKTLEPIP KEENAEEDDE SEWSDDEPEV VREKLYTLGT KLMELGIKNA 540
  541 NGVEIIFNIN KDGALRVTAR DLKTGNAVKG EL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..207]
    [407..428]    		 PSI-BLAST 1526.9897 Heat shock protein 70kDa, ATPase fragment
    2 View Details [208..264]
    [340..406]    		 PSI-BLAST 1526.9897 Heat shock protein 70kDa, ATPase fragment
    3 View Details [265..339] PSI-BLAST 1526.9897 Heat shock protein 70kDa, ATPase fragment
    4 View Details [429..572] PSI-BLAST 47.39794 DnaK


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle