Protein Overview: YHK8

General Information:
Name(s) found:	YHK8 / YHR048W [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles [SGD]
Organism:	Saccharomyces cerevisiae
Length:	514 amino acids
Gene Ontology:
Cellular Component:	integral to membrane [ISS]
Biological Process:	drug transport [IEP][ISS]
Molecular Function:	drug transmembrane transporter activity [IEP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAEFQIASA QSSALTSTEE EHCSINSDKA AKLDLELTSE RKNDGKQSHE VTFNEDIADP  60
   61 EDIARHMSTA RRYYISSLIT FTSMVITMIS SSWTLPSTHI IEHFHISHEV STLGITLYVF 120
  121 GLGIGPLFLS PLSELYGRRI TFLYALTLSI IWQCLTIWSK TITGVMFGRF LSGFFGSAFL 180
  181 SVAGGAIADI FDKDQIGIPM AIYTTSAFLG PSLGPIIGGA LYHQSYKWTF ITLLITSGCC 240
  241 LVMIIFTIPE TYKPMLLIRK AKRLRKEKND QRYYAVLEVT REQTSLLSAI FLSTKRPFGL 300
  301 LLRDRMMGVL CFYTGLELAI IYLYFVAFPY VFKKLYNFGP MEIACSYIGI MVGMILSAPT 360
  361 CLLFQKTFEW RVKRNNGVKT PEMRFEPLFY GAFLTPVGLF IFAFTCYKHV HWIAPIIGSA 420
  421 IFGSGVYFVF TGVFAYTVDA YRRYAASGMA CNTFVRCIMA GVFPLFGLQM YKSMGVNWAG 480
  481 FLLAMVTVAM IPVPFLFTKY GARLRAKSPY AWDD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		QDR1 QDR3 YHK8

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.24937104052238	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
binding	1.01584233411372	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..514]	PSI-BLAST	10.221849	No description for 1ja5A_ was found.

Protein Overview: YHK8

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: