YRC Public Data Repository - Protein Structure Prediction

Protein:	YHK8
Organism:	Saccharomyces cerevisiae
Length:	514 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHK8.

Description	E-value	Query Range	Subject Range
YCT4_SCHPO - Uncharacterized transporter C794.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC7... SPCC794.04c - membrane transporter	4.0E-91	[6..513]	[45..546]
YHK8 - Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted t... gi\|151943993 - gi\|151943993\|gb\|EDN62286.1\| conserved protein [Saccharomyces cerevisiae YJM789] gi\|207344711 - gi\|207344711\|gb\|EDZ71764.1\| YHR048Wp-like protein [Saccharomyces cerevisiae AWRI1631] YHK8_YEAST - Probable drug/proton antiporter YHK8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YHK...	2.0E-90	[1..514]	[1..514]
gi\|9801985, gi\|7... - gi\|9801985\|gb\|AAF99573.1\|AF188621_1 fluconazole resistance protein [Candida albicans], gi\|76573588\|d... gi\|68469252, gi\|... - gi\|77022662\|ref\|XP_888775.1\| hypothetical protein CaO19_6577 [Candida albicans SC5314], gi\|68470277\|...	1.0E-85	[6..512]	[98..607]
gi\|223644446, gi... - gi\|241956766\|ref\|XP_002421103.1\| multidrug transporter; plasma membrane transporter of the major fac... gi\|2951670 - gi\|2951670\|emb\|CAA12730.1\| multidrug transporter [Candida dubliniensis]	1.0E-81	[2..511]	[40..556]
gi\|5420310 - gi\|5420310\|emb\|CAB46647.1\| putative multiple drug resistance protein [Penicillium olsonii]	4.0E-81	[37..511]	[52..531]

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Predicted Domain #1

Region A:
Residues: [1-514]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAEFQIASA QSSALTSTEE EHCSINSDKA AKLDLELTSE RKNDGKQSHE VTFNEDIADP  60
   61 EDIARHMSTA RRYYISSLIT FTSMVITMIS SSWTLPSTHI IEHFHISHEV STLGITLYVF 120
  121 GLGIGPLFLS PLSELYGRRI TFLYALTLSI IWQCLTIWSK TITGVMFGRF LSGFFGSAFL 180
  181 SVAGGAIADI FDKDQIGIPM AIYTTSAFLG PSLGPIIGGA LYHQSYKWTF ITLLITSGCC 240
  241 LVMIIFTIPE TYKPMLLIRK AKRLRKEKND QRYYAVLEVT REQTSLLSAI FLSTKRPFGL 300
  301 LLRDRMMGVL CFYTGLELAI IYLYFVAFPY VFKKLYNFGP MEIACSYIGI MVGMILSAPT 360
  361 CLLFQKTFEW RVKRNNGVKT PEMRFEPLFY GAFLTPVGLF IFAFTCYKHV HWIAPIIGSA 420
  421 IFGSGVYFVF TGVFAYTVDA YRRYAASGMA CNTFVRCIMA GVFPLFGLQM YKSMGVNWAG 480
  481 FLLAMVTVAM IPVPFLFTKY GARLRAKSPY AWDD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.221849
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.24937104052238	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
binding	1.01584233411372	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: