Protein Overview: DOG2

General Information:
Name(s) found:	DOG2 / YHR043C [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed [SGD]
Organism:	Saccharomyces cerevisiae
Length:	246 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA ]
Biological Process:	glucose metabolic process [ISS] ER-associated protein catabolic process [IMP] response to stress [IEP]
Molecular Function:	2-deoxyglucose-6-phosphatase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQFSVDLCL FDLDGTIVST TTAAESAWKK LCRQHGVDPV ELFKHSHGAR SQEMMKKFFP  60
   61 KLDNTDNKGV LALEKDMADN YLDTVSLIPG AENLLLSLDV DTETQKKLPE RKWAIVTSGS 120
  121 PYLAFSWFET ILKNVGKPKV FITGFDVKNG KPDPEGYSRA RDLLRQDLQL TGKQDLKYVV 180
  181 FEDAPVGIKA GKAMGAITVG ITSSYDKSVL FDAGADYVVC DLTQVSVVKN NENGIVIQVN 240
  241 NPLTRD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		CDC12 DOG1 DOG2 GUS1 IMD4 MET6 MSK1 PYC1 RGD1 SEC53 TMA19 VMA22

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NAF1	DOG2	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	DOG2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..20] [79..246]	PSI-BLAST	27.69897	L-2-Haloacid dehalogenase, HAD
2	View Details	[21..78]	PSI-BLAST	27.69897	L-2-Haloacid dehalogenase, HAD

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.91

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2