Protein Overview: ARN1

General Information:
Name(s) found:	ARN1 / YHL040C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731616\|sp\|P38731.1\|ARN1_YEAST RecName: Full=Siderophore iron transporter ARN1; AltName: Full=Ferrichrome permease [NCBI NR] gi\|6321747\|ref\|NP_011823.1\| Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; Arn1p [Saccharomyces cerevi [NCBI NR] pir\|\|S48928 hypothetical protein YHL040c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|2289869\|gb\|AAB65052.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] Siderophore iron transporter ARN1 OS=Saccharomyces cerevisiae GN=ARN1 PE=1 SV=1 [Swiss-Prot] ARN1 Transporter of ferrirubin, ferrirhodin and other ferrichromes [mips] Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores [SGD] ARN1, Chr VIII from 19085-20968, reverse complement [yeast_orfs2] Chr VIII from 19085-20968, reverse complement [yeastorf3.fasta] Chr VIII from 20968-19085, reverse complement [yeastorf5.fasta] (P38731) Hypothetical 70.9 kDa protein in CBP2 5'region [4932.FASTACCERV.txt] ARN1 SGDID:S0001032, Chr VIII from 20968-19085, reverse complement, Verified ORF [yeastflysequest.fasta] Arn1p [Saccharomyces cerevisiae]gi\|2289869\|gb\|AAB65052.1\| Similar to hypothetical 13.2 kd protein and hypothetical 15.4 kd protein in HML 5' region [Saccharomyces cerevisiae]gi\|626582\|pir\|\|S48928 hypothetical protein YHL040c - yeast (Saccharomyces cerev [nrdb_11152004_Chlamydomonas] (P38731) Siderophore iron transporter ARN1 (Ferrichrome permease) [cerv4932.FASTAC] ARN1 SGDID:S000001032, Chr VIII from 20968-19085, reverse complement, Verified ORF, "Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhod [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; Arn1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Siderophore iron transporter ARN1 (Ferrichrome permease) [nr-271106-contam.fasta] ARN1 SGDID:S000001032, Chr VIII from 20968-19085, reverse complement, Verified ORF, "Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Siderophore iron transporter ARN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARN1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ARN1 SGDID:S000001032, Chr VIII from 20971-19088, Genome Release 64-1-1, reverse complement, Verified ORF, "Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores" [yeast-030211-contam.fasta] ARN1 SGDID:S000001032, Chr VIII from 20971-19088, Genome Release 64-2-1, reverse complement, Verified ORF, "ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress" [20141208_orf_trans.fasta] YHL040C SGDID:S000001032, Chr VIII from 20971-19088, Genome Release 64-1-1, reverse complement, Verified ORF, "Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	627 amino acids
Gene Ontology:
Cellular Component:	endosome [TAS] cytoplasmic membrane-bounded vesicle [IDA]
Biological Process:	siderophore-iron transport [IMP]
Molecular Function:	siderophore-iron transmembrane transporter activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESVHSRDPV KEEKKHVFMG MEHELNPETH NDSNSDSYGL PQLSEKYNAL RQNRSLIIQQ  60
   61 TEIIGSAYNK WYLQAILLLS AFICGYGYGL DGNIRYIYTG YATSSYSEHS LLSTINVINA 120
  121 VVSAASQIIY ARLSDVFGRL YLFISAVILY VVGTIIQSQA YDVQRYAAGA IFYNAGYVGV 180
  181 ILILLIILSD FSSLKWRLLY QFVPTWPFII NTWIAGNITS RANPVVNWSW DVGMWAFIFP 240
  241 LSCVPIVLCM LHMQWRARKT PEWHALKGQK SYYQEHGFIK ILKQLFWMLD VVGVLLMGCS 300
  301 LGCILVPLTL AGGVKTTWND SRLIGPFVLG FVLIPILWIW EYRFARDPIL PYRLVKDRAV 360
  361 WSSMGISFLI DFIYYMAADY LYTVMIVAVN ESVKSATRIA TLSSFVSTVA SPFFALLVTR 420
  421 CTRLKPFIMF GCALWMVAMG LLYHFRGGSQ SHSGIIGALC VWGVGTTLFT YPVTVSVQSA 480
  481 VSHENMATVT ALNYTLYRIG SAVGSAVSGA IWTQTLYKQI LKRMGDVALA TTAYESPYTF 540
  541 IETYTWGTPQ RNALMNAYKY VQRLETIVAL VFCVPLIAFS LCLRDPKLTD TVAVEYIEDG 600
  601 EYVDTKDNDP ILDWFEKLPS KFTFKRE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		ARN1 ARN2 ENB1 SIT1 SMF2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ROM1	ARN1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ARN1 and SNF7	Huh WK, et al. (2003)
View Data	ARN1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..69]	deduced	N/A	No confident structure predictions are available.
2	View Details	[70..260]	PSI-BLAST	9.154902	No description for 1lviA_ was found.
3	View Details	[261..320]	deduced	N/A	No confident structure predictions are available.
4	View Details	[321..544]	MSA	36.627996	View MSA. No confident structure predictions are available.
5	View Details	[545..627]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
cation transmembrane transporter activity	4.31967711223954	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
binding	1.26757615356623	bayes_pls_golite062009
anion transmembrane transporter activity	1.24023641504332	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2