YRC Public Data Repository - Protein Structure Prediction

Protein:	ARN1
Organism:	Saccharomyces cerevisiae
Length:	627 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARN1.

Description	E-value	Query Range	Subject Range
ARN1_YEAST - Siderophore iron transporter ARN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARN1 P... ARN1 - Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron c...	0.0	[1..627]	[1..627]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	2.0E-87	[59..608]	[16..539]
gi\|19386936 - gi\|19386936\|gb\|AAL87047.1\|AF448056_3 putative dothistromin transporter [Mycosphaerella pini] gi\|19386936 - gi\|19386936\|gb\|AAL87047.1\|AF448056_3 putative dothistromin transporter [Mycosphaerella pini]	5.0E-84	[1..591]	[1..569]
gi\|16944692 - gi\|16944692\|emb\|CAC28808.2\| related to tetracycline efflux protein (otrb) [Neurospora crassa]	1.0E-80	[30..597]	[1..564]
gi\|14389419 - gi\|14389419\|gb\|AAF64435.2\|AF238225_1 DHA14-like major facilitator [Botryotinia fuckeliana]	2.0E-80	[7..591]	[34..591]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-80	[47..591]	[10..533]
gi\|15927932, gi\|... - gi\|15927932\|ref\|NP_375465.1\| hypothetical protein SA2142 [Staphylococcus aureus subsp. aureus N315],... gi\|253314692 - gi\|253314692\|ref\|ZP_04837905.1\| hypothetical protein SauraC_00665 [Staphylococcus aureus subsp. aure... gi\|12003106, gi\|... - pir\|\|C90035 hypothetical protein SA2142 [imported] - Staphylococcus aureus (strain N315), gi\|120031... gi\|255007128 - gi\|255007128\|ref\|ZP_05145729.2\| hypothetical protein SauraM_11685 [Staphylococcus aureus subsp. aure... gi\|14248126, gi\|... - gi\|15925342\|ref\|NP_372876.1\| multidrug resistance protein [Staphylococcus aureus subsp. aureus Mu50]... gi\|269203983\|ref... - EmrB/QacA family drug resistance transporter [Staphylococcus aureus subsp. aureus ED98] gi\|90583610, gi\|... - gi\|90583610\|ref\|ZP_01239364.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|147741858, gi... - gi\|90585929\|ref\|ZP_01241634.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|156980667, gi... - gi\|156980667\|ref\|YP_001442926.1\| hypothetical protein SAHV_2336 [Staphylococcus aureus subsp. aureus...	3.0E-80	[1..599]	[66..636]
gi\|15528453 - gi\|15528453\|emb\|CAC69145.1\| putative membrane protein [Pichia anomala]	5.0E-80	[1..601]	[26..609]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	4.0E-79	[71..586]	[9..501]

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Predicted Domain #1

Region A:
Residues: [1-69]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESVHSRDPV KEEKKHVFMG MEHELNPETH NDSNSDSYGL PQLSEKYNAL RQNRSLIIQQ  60
   61 TEIIGSAYN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
cation transmembrane transporter activity	4.31967711223954	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
binding	1.26757615356623	bayes_pls_golite062009
anion transmembrane transporter activity	1.24023641504332	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [70-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KWYLQAILLL SAFICGYGYG LDGNIRYIYT GYATSSYSEH SLLSTINVIN AVVSAASQII  60
   61 YARLSDVFGR LYLFISAVIL YVVGTIIQSQ AYDVQRYAAG AIFYNAGYVG VILILLIILS 120
  121 DFSSLKWRLL YQFVPTWPFI INTWIAGNIT SRANPVVNWS WDVGMWAFIF PLSCVPIVLC 180
  181 MLHMQWRARK T

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.154902
Match:	1lviA_
Description:	No description for 1lviA_ was found.

Predicted Domain #3

Region A:
Residues: [261-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEWHALKGQK SYYQEHGFIK ILKQLFWMLD VVGVLLMGCS LGCILVPLTL AGGVKTTWND  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [321-544]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRLIGPFVLG FVLIPILWIW EYRFARDPIL PYRLVKDRAV WSSMGISFLI DFIYYMAADY  60
   61 LYTVMIVAVN ESVKSATRIA TLSSFVSTVA SPFFALLVTR CTRLKPFIMF GCALWMVAMG 120
  121 LLYHFRGGSQ SHSGIIGALC VWGVGTTLFT YPVTVSVQSA VSHENMATVT ALNYTLYRIG 180
  181 SAVGSAVSGA IWTQTLYKQI LKRMGDVALA TTAYESPYTF IETY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [545-627]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TWGTPQRNAL MNAYKYVQRL ETIVALVFCV PLIAFSLCLR DPKLTDTVAV EYIEDGEYVD  60
   61 TKDNDPILDW FEKLPSKFTF KRE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: