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Protein Overview: HSE1

General Information:
Name(s) found: HSE1 / YHL002W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 452 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article]
    Biological Process: protein targeting to vacuole [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSAIKIRN ALLKATDPKL RSDNWQYILD VCDLVKEDPE DNGQEVMSLI EKRLEQQDAN  60
   61 VILRTLSLTV SLAENCGSRL RQEISSKNFT SLLYALIESH SVHITLKKAV TDVVKQLSDS 120
  121 FKDDPSLRAM GDLYDKIKRK APYLVQPNVP EKHNMSTQAD NSDDEELQKA LKMSLFEYEK 180
  181 QKKLQEQEKE SAEVLPQQQQ QHQQQNQAPA HKIPAQTVVR RVRALYDLTT NEPDELSFRK 240
  241 GDVITVLEQV YRDWWKGALR GNMGIFPLNY VTPIVEPSKE EIEKEKNKEA IVFSQKTTID 300
  301 QLHNSLNAAS KTGNSNEVLQ DPHIGDMYGS VTPLRPQVTR MLGKYAKEKE DMLSLRQVLA 360
  361 NAERSYNQLM DRAANAHISP PVPGPALYAG MTHANNTPVM PPQRQSYQSN EYSPYPSNLP 420
  421 IQHPTNSANN TPQYGYDLGY SVVSQPPPGY EQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HSE1 VPS27
    View Details Krogan NJ, et al. (2006) HSE1 VPS27
    View Details Gavin AC, et al. (2006) HSE1 VPS27
    View Details Gavin AC, et al. (2002) HSE1 VPS27

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HSE1 Huh WK, et al. (2003)
    View Data HSE1 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] PSI-BLAST 132.594777 Tom1 protein
    2 View Details [79..146] PSI-BLAST 132.594777 Tom1 protein
    3 View Details [147..207] deduced N/A No confident structure predictions are available.
    4 View Details [208..303] PSI-BLAST 137.94696 Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
    5 View Details [304..452] PSI-BLAST 137.94696 Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.47621789723131 bayes_pls_golite062009
  • protein binding
    		•  2.10925438883926 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.29637592432055 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.02097165614658 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.938262449967509 bayes_pls_golite062009
  • transporter activity
    		•  0.781252315942763 bayes_pls_golite062009
  • hydrolase activity
    		•  0.539213162060111 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.523669943250984 bayes_pls_golite062009
  • actin binding
    		•  0.4786890657602 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.476094076158571 bayes_pls_golite062009
  • structural molecule activity
    		•  0.236653863910566 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.207376833349132 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.151103447043301 bayes_pls_golite062009
  • DNA binding
    		•  0.143439914163001 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.125965304296204 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle