Protein Overview: MGA1

General Information:
Name(s) found:	MGA1 / YGR249W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321688\|ref\|NP_011765.1\| Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants; Mga1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S47924 MGA1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|511951\|dbj\|BAA06105.1\| ORF [Saccharomyces cerevisiae] [NCBI NR] gi\|1709016\|sp\|P53050.1\|MGA1_YEAST RecName: Full=Protein MGA1 [NCBI NR] gi\|1702958\|emb\|CAA68970.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1323452\|emb\|CAA97278.1\| MGA1 [Saccharomyces cerevisiae] [NCBI NR] Protein MGA1 OS=Saccharomyces cerevisiae GN=MGA1 PE=2 SV=1 [Swiss-Prot] MGA1 Regulator of pseudohyphal differentiation [mips] Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants [SGD] MGA1, Chr VII from 988045-989415 [yeast_orfs2] Chr VII from 988045-989415 [yeastorf3.fasta] Chr VII from 988052-989422 [yeastorf4.fasta] (P53050) MGA1 protein [4932.FASTACCERV.txt] MGA1 SGDID:S0003481, Chr VII from 988053-989423, Verified ORF [yeastflysequest.fasta] MGA1 SGDID:S0003481, Chr VII from 988054-989424, Verified ORF [10112005cervSGD.fasta] Mga1p [Saccharomyces cerevisiae]gi\|1323452\|emb\|CAA97278.1\| MGA1 [Saccharomyces cerevisiae]gi\|1702958\|emb\|CAA68970.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|626736\|pir\|\|S47924 MGA1 protein - yeast (Saccharomyces cerevisiae)gi\|511951\|dbj\|B [nrdb_11152004_Chlamydomonas] MGA1 SGDID:S000003481, Chr VII from 988054-989424, Verified ORF, "Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants; Mga1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein MGA1 [nr-271106-contam.fasta] MGA1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ORF [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Protein MGA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MGA1 PE=2 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MGA1 SGDID:S000003481, Chr VII from 988049-989419, Genome Release 64-1-1, Verified ORF, "Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants" [yeast-030211-contam.fasta] Protein MGA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MGA1 PE=3 SV=1 [YEAST.fasta.20131015] MGA1 SGDID:S000003481, Chr VII from 988049-989419, Genome Release 64-2-1, Verified ORF, "Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants" [20141208_orf_trans.fasta] YGR249W SGDID:S000003481, Chr VII from 988049-989419, Genome Release 64-1-1, Verified ORF, "Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	456 amino acids
Gene Ontology:
Cellular Component:	nucleus [IC]
Biological Process:	filamentous growth [IGI]
Molecular Function:	DNA binding [IDA] transcription factor activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPKTFVHQL HAILLEPEVN KWIYWSPTDN TVFFLKPYDP NFSTHVLKRY FKHGNVNSFV  60
   61 RQLHMYGFHK LSHPSPDQSS ANNGNVKELV EWKFTHPSGF FFKEANAGIL NKIQRKSTGV 120
  121 GKDGKRKNIL SPISVSYVDA SRLNVLSQQS GPVSAREPSN MFMGSPVHYS TSQSPPHISI 180
  181 PQQQQSSGPY LISSLPPQQP TVNMMRRQSI SARMMNSYDY PNQFSTQDSI VQPQQPQQVL 240
  241 SPQALSGPPM KKSGTLSSTD DLKTTSLPIV NYPMPYHPGA FAQQQQQQQQ PLPTVPPYSS 300
  301 YSTPFPSMMN SLSNSASNSP ALGVCNNNVT LPKKSNISER QALDNHIQTL KNSLSTITDL 360
  361 IEKHINSASQ DENKTLTNDA MNKDLRTSLS LLQNSKEEII QLESKWMSMQ SVKTTALPLQ 420
  421 ETTNTSSTLT SLTSSIIPKS IPIITKGEVA TKPASY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LSM2	MGA1	1	Unpublished Fields Lab Data
View Screen	RAD9	MGA1	1	Unpublished Fields Lab Data
View Screen	ESS1	MGA1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..117]	PSI-BLAST	129.70927	Heat-shock transcription factor
2	View Details	[118..456]	ORFEUS	14.93	RBP1

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transcription regulator activity	2.69048535857291	bayes_pls_golite062009
nucleic acid binding	2.64324711228084	bayes_pls_golite062009
DNA binding	2.61442118042246	bayes_pls_golite062009
binding	2.37880408751912	bayes_pls_golite062009
transcription factor activity	1.88900792328916	bayes_pls_golite062009
sequence-specific DNA binding	0.68922344928172	bayes_pls_golite062009
transcription activator activity	0.485327753327262	bayes_pls_golite062009
transcription repressor activity	0.385147412723772	bayes_pls_golite062009
protein binding	0.35301104350965	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2