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Protein Overview: KEL2

General Information:
Name(s) found: KEL2 / YGR238C [SGD]
Description(s) found:
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  • gi|886933|emb|CAA61189.1| ORF 882 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6321677|ref|NP_011754.1| Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; Kel2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013521|gb|AAT93054.1| YGR238C [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1723756|sp|P50090.1|KEL2_YEAST RecName: Full=Kelch repeat-containing protein 2 [NCBI NR]
  • pir||S57704 hypothetical protein YGR238c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1323431|emb|CAA97266.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Kelch repeat-containing protein 2 OS=Saccharomyces cerevisiae GN=KEL2 PE=1 SV=1 [Swiss-Prot]
  • KEL2 Protein involved in cell fusion and morphogenesis [mips]
  • Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate [SGD]
  • KEL2, Chr VII from 966035-968683, reverse complement [yeast_orfs2]
  • Chr VII from 966035-968683, reverse complement [yeastorf3.fasta]
  • Chr VII from 966042-968690, reverse complement [yeastorf4.fasta]
  • Chr VII from 968690-966042, reverse complement [yeastorf5.fasta]
  • (P50090) Kelch repeats protein 2 [4932.FASTACCERV.txt]
  • KEL2 SGDID:S0003470, Chr VII from 968691-966043, reverse complement, Verified ORF [yeastflysequest.fasta]
  • KEL2 SGDID:S0003470, Chr VII from 968692-966044, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Kel2p [Saccharomyces cerevisiae]gi|51013521|gb|AAT93054.1| YGR238C [Saccharomyces cerevisiae]gi|886933|emb|CAA61189.1| ORF 882 [Saccharomyces cerevisiae]gi|1323431|emb|CAA97266.1| unnamed protein product [Saccharomyces cerevisiae]gi|1362338|pir||S5770 [nrdb_11152004_Chlamydomonas]
  • KEL2 SGDID:S000003470, Chr VII from 968692-966044, reverse complement, Verified ORF, "Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential C [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YGR238C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ORF 882 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; Kel2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Kelch repeat-containing protein 2 [nr-271106-contam.fasta]
  • KEL2 SGDID:S000003470, Chr VII from 968692-966044, reverse complement, Verified ORF, "Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Kelch repeat-containing protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KEL2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • KEL2 SGDID:S000003470, Chr VII from 968687-966039, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate" [yeast-030211-contam.fasta]
  • KEL2 SGDID:S000003470, Chr VII from 968687-966039, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein that negatively regulates mitotic exit; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL2 has a paralog, KEL1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YGR238C SGDID:S000003470, Chr VII from 968687-966039, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 882 amino acids

    Gene Ontology:
    Cellular Component: cellular bud tip [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    mating projection tip [IDALink to PubMed article]
    Biological Process: negative regulation of exit from mitosis [IMPLink to PubMed article][IPILink to PubMed article]
    conjugation with cellular fusion [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVPFKLTNKV PTDTGPSLIS AQSVPRPIVF MDNRNNTRIV TPTLPPNQHR GISGASTALP  60
   61 WSPESKNTGK YIWNRVKLKN SPFPRYRHSS SFIVTNDNRI FVTGGLHDQS VYGDVWQIAA 120
  121 NADGTSFTSK RIDIDQNTPP PRVGHASTIC GNAYVVFGGD THKLNKNGLL DDDLYLFNIN 180
  181 SYKWTIPQPI GRRPLGRYGH KISIIASNPM QTKLYLFGGQ VDETYFNDLV VFDLSSFRRP 240
  241 NSHWEFLEPV GDLPPPLTNH TMVAYDNKLW VFGGETPKTI SNDTYRYDPA QSEWSKVKTT 300
  301 GEKPPPIQEH ASVVYKHLMC VLGGKDTHNA YSNDVYFLNL LSLKWYKLPR MKEGIPQERS 360
  361 GHSLTLMKNE KLLIMGGDKT DYASPNIHDL QTSETDQGEG TLLYTLDLSS LNELCPGIMC 420
  421 ESLHAGESFS NSLSGGFTPS KSTESENQEI INILTPRLPD SKVLSYNDID EGAGSYSSAL 480
  481 DDKAFERKSD REEKKPQSSK VDSSINKESP GTGIKVSKKN FPVLRGLTVD SEEYGSSSYK 540
  541 DTSCQKGIPK NLFDDLNLNL QTLRLEAQQK ELETARHISQ LEKEVQRLMV IKEASKDSNF 600
  601 QTARLKNLEI QKTFLESRIN DLKNLLMVKL SQASKLCDQI TIQNNGLKTC SEHVTIKRDI 660
  661 IDLENKCDVL KRQNEILVNN MQKITPELHT YLNESSCYLG KLLKSYPTSA RPPSSEKDNQ 720
  721 IYEKDSLNKI EKVINEMHET VRAKEKLHLE TQKLNDERDS LRANLLDNNN KLDALRKLSD 780
  781 GSSKSMDLTK KAIHLSQSEL EKYRKNNDDL QKEIDRIKTE QAEQDDKQEQ RGAITHGNFD 840
  841 AFHRMKINNL KAELYMSKEN RDSLKDELLA LKKKLYTLEQ KK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) KEL2 MYO3 SEN1 SSE2 YPS7
    View Details (MIPS) Mewes HW, et al. (2004) KEL1 KEL2
    View Details Krogan NJ, et al. (2006) KEL1 KEL2 KIP2 YER184C
    View Details Ho Y, et al. (2002) BUD14 CMP2 DOG1 GIS4 HSP104 KEL1 KEL2 KIN2 KRE6 POP2 TEF4 TFC4 UBA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KEL2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..214] ORFEUS 14.75 Galactose oxidase, C-terminal domain; Galactose oxidase, N-terminal domain; Galactose oxidase, central domain
    2 View Details [215..347] PSI-BLAST 6.154902 Galactose oxidase, C-terminal domain; Galactose oxidase, N-terminal domain; Galactose oxidase, central domain
    3 View Details [348..674] PSI-BLAST 29.221849 Heavy meromyosin subfragment
    4 View Details [675..882] PSI-BLAST 3.522879 Tropomyosin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle