Protein Overview: AZR1

General Information:
Name(s) found:	AZR1 / YGR224W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|886916\|emb\|CAA61172.1\| ORF 613 [Saccharomyces cerevisiae] [NCBI NR] gi\|6321663\|ref\|NP_011740.1\| Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole; Azr1p [Saccharomyces cerevisiae] [NCBI NR] gi\|1723746\|sp\|P50080.1\|AZR1_YEAST RecName: Full=Azole resistance protein 1 [NCBI NR] pir\|\|S57687 probable membrane protein YGR224w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1323404\|emb\|CAA97252.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P50080) Hypothetical transport protein YGR224W [Swiss-Prot] Azole resistance protein 1 OS=Saccharomyces cerevisiae GN=AZR1 PE=1 SV=1 [Swiss-Prot] AZR1 Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs [mips] Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole [SGD] AZR1, Chr VII from 942799-944640 [yeast_orfs2] Chr VII from 942799-944640 [yeastorf3.fasta] Chr VII from 942806-944647 [yeastorf4.fasta] (P50080) Hypothetical 67.2 kDa protein in PET54-DIE2 intergenic region [4932.FASTACCERV.txt] AZR1 SGDID:S0003456, Chr VII from 942807-944648, Verified ORF [yeastflysequest.fasta] AZR1 SGDID:S0003456, Chr VII from 942809-944650, Verified ORF [10112005cervSGD.fasta] Azr1p [Saccharomyces cerevisiae]gi\|886916\|emb\|CAA61172.1\| ORF 613 [Saccharomyces cerevisiae]gi\|1323404\|emb\|CAA97252.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1362333\|pir\|\|S57687 probable membrane protein YGR224w - yeast (Saccharomyces cer [nrdb_11152004_Chlamydomonas] AZR1 SGDID:S000003456, Chr VII from 942809-944650, Verified ORF, "Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole; Azr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Azole resistance protein 1 [nr-271106-contam.fasta] ORF 613 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Azole resistance protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AZR1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] AZR1 SGDID:S000003456, Chr VII from 942806-944647, Genome Release 64-1-1, Verified ORF, "Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole" [yeast-030211-contam.fasta] AZR1 SGDID:S000003456, Chr VII from 942806-944647, Genome Release 64-2-1, Verified ORF, "Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole" [20141208_orf_trans.fasta] YGR224W SGDID:S000003456, Chr VII from 942806-944647, Genome Release 64-1-1, Verified ORF, "Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	613 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA]
Biological Process:	azole transport [IMP]
Molecular Function:	azole transporter activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGEPKTYSM SDLSYYGEKA QQQNEKQQKQ YVVRRNSTQS TSKQNVSVVL EDNASESNEL  60
   61 PKGFILYASL IALALSLFLA ALDIMIVSTI IEEVAKQFGS YSEIGWLFTG YSLPNALLAL 120
  121 IWGRIATPIG FKETMLFAIV IFEIGSLISA LANSMSMLIG GRVIAGVGGC GIQSLSFVIG 180
  181 STLVEESQRG ILIAVLSCSF AIASVVGPFL GGVFTSSVTW RWCFYVNLPI GGLAFFLFLF 240
  241 FYNPGLSTFQ ETMDNIRKFP SQFIEIVRNV AYHLLKIKGF SKLNGWRKPF MELIFMYDII 300
  301 EFVFCSAGFT CILLAFTFGG NRYAWNSASI IILFIIGIVL VVLAGIYDFL VFPKFNIVKA 360
  361 TPHYQPLMSW TNIKKPGIFT VNIALFLTCA GYISQFTYIV QYFQLIYNDS AWRAAVHLVA 420
  421 CIISTVVTAI LCGAITDKTR QIKPIIVISS IFGVVGAGIL TLLNNNANNS AHIGLLILPG 480
  481 VAFGGLAQSS MLASQIQLDK KSPTFRSDFV SITTFNTFCK NLGQALGGVI SNTVFSAAAI 540
  541 KKLTKANIQL PDGTTVDNLV IYRQTNFDGS HSKLGNIISE SLTDVFYMAL GFYALSLIFA 600
  601 VFASNKKVTA SLR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		AZR1 QDR1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ASF1	sample 3928 - Asf1-S-TEV-ZZ (in hir3delta mutant)	Green EM, et al (2005)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC13	AZR1	1	Unpublished Fields Lab Data
View Screen	PRR1	AZR1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..465]	PSI-BLAST	9.0	No description for 1lviA_ was found.
2	View Details	[466..613]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
binding	1.01584233411372	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2