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Protein Overview: IRC7

General Information:
Name(s) found: IRC7 / YFR055W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 340 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: cellular copper ion homeostasis [IEPLink to PubMed article]
    sulfur metabolic process [ISSLink to PubMed article]
    Molecular Function: cystathionine beta-lyase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDRTELSKF GITTQLSVIG RNPDEQSGFV NPPLYKGSTI ILKKLSDLEQ RKGRFYGTAG  60
   61 SPTIDNLENA WTHLTGGAGT VLSASGLGSI SLALLALSKA GDHILMTDSV YVPTRMLCDG 120
  121 LLAKFGVETD YYDPSIGKDI EKLVKPNTTV IFLESPGSGT MEVQDIPALV SVAKKHGIKT 180
  181 ILDNTWATPL FFDAHAHGID ISVEAGTKYL GGHSDLLIGL ASANEECWPL LRSTYDAMAM 240
  241 LPGAEDCQLA LRGMRTLHLR LKEVERKALD LAAWLGNRDE VEKVLHPAFE DCPGHEYWVR 300
  301 DYKGSSGLFS IVLKNGFTRA GLEKMVEGMK VLQLGFSWGG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BUD5 IRC7 PHO11 PHO5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..340] PSI-BLAST 781.30103 Cystathionine beta-lyase, CBL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.59895155864374 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.59895155864374 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  1.27059944776392 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • ligase activity
    		•  0.827063849687833 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.6849039330512 bayes_pls_golite062009
  • cystathionine gamma-lyase activity
    		•  0.505859361763689 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.271623203801431 bayes_pls_golite062009
  • binding
    		•  0.252160165096264 bayes_pls_golite062009
  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity
    		•  0.234399054481664 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  0.0669652799570574 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0221593597423818 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle