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View Structure Prediction Details

Protein: IRC7
Organism: Saccharomyces cerevisiae
Length: 340 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IRC7.

Description E-value Query
Range		 Subject
Range
gi|13699175, gi|... - gi|51261011|gb|AAH78869.1| Cystathionase (cystathionine gamma-lyase) [Rattus norvegicus], gi|1403106...
 0.0 [11..340] [16..342]
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori (strain ATCC 700392 / 26695) GN=metB PE=1 SV=1
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori GN=metB PE=3 SV=1
 0.0 [14..340] [5..325]
CGL_MOUSE - Cystathionine gamma-lyase OS=Mus musculus GN=Cth PE=1 SV=1
 0.0 [1..340] [1..342]
MEGL_FUSNN - L-methionine gamma-lyase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130...
 0.0 [6..339] [2..340]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..340] [1..338]
METC_LACLM - Cystathionine beta-lyase OS=Lactococcus lactis subsp. cremoris (strain MG1363) GN=metC PE=1 SV=1
METC_LACLA - Cystathionine beta-lyase OS=Lactococcus lactis subsp. lactis GN=metC PE=3 SV=1
METC_LACLC - Cystathionine beta-lyase (EC 4.4.1.8) (CBL) (Beta-cystathionase) (Cysteine lyase) - Lactococcus lact...
METC_LACLA - Cystathionine beta-lyase OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=metC PE=3 SV=1
 0.0 [12..340] [4..326]
gi|5104901, gi|1... - gi|5104901|dbj|BAA80215.1| cystathionine gamma-lyase [Aeropyrum pernix K1], gi|14601268|ref|NP_14780...
gi|7437088 - pir||A72595 probable cystathionine gamma-lyase APE1226 - Aeropyrum pernix (strain K1)
 0.0 [11..340] [3..330]
gi|188993147, gi... - gi|188993147|ref|YP_001905157.1| Cys/Met metabolism PLP-dependent enzyme [Xanthomonas campestris pv....
 0.0 [1..340] [1..342]
gi|9929259 - gi|9929259|emb|CAC05298.1| cystathionine beta-lyase [Lactobacillus reuteri]
 0.0 [12..340] [3..325]

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Predicted Domain #1
Region A:
Residues: [1-340] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDRTELSKF GITTQLSVIG RNPDEQSGFV NPPLYKGSTI ILKKLSDLEQ RKGRFYGTAG  60
   61 SPTIDNLENA WTHLTGGAGT VLSASGLGSI SLALLALSKA GDHILMTDSV YVPTRMLCDG 120
  121 LLAKFGVETD YYDPSIGKDI EKLVKPNTTV IFLESPGSGT MEVQDIPALV SVAKKHGIKT 180
  181 ILDNTWATPL FFDAHAHGID ISVEAGTKYL GGHSDLLIGL ASANEECWPL LRSTYDAMAM 240
  241 LPGAEDCQLA LRGMRTLHLR LKEVERKALD LAAWLGNRDE VEKVLHPAFE DCPGHEYWVR 300
  301 DYKGSSGLFS IVLKNGFTRA GLEKMVEGMK VLQLGFSWGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 781.30103
Match: 1cl2A_
Description: Cystathionine beta-lyase, CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 2.29878871754893 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 1.59895155864374 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 1.59895155864374 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 1.27059944776392 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
ligase activity 0.827063849687833 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
carbon-sulfur lyase activity 0.698312655247044 bayes_pls_golite062009
cystathionine beta-lyase activity 0.6849039330512 bayes_pls_golite062009
cystathionine gamma-lyase activity 0.505859361763689 bayes_pls_golite062009
glycine hydroxymethyltransferase activity 0.271623203801431 bayes_pls_golite062009
binding 0.252160165096264 bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity 0.234399054481664 bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity 0.0669652799570574 bayes_pls_golite062009
nucleic acid binding 0.0221593597423818 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle