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Protein Overview: ECO1

General Information:
Name(s) found: ECO1 / YFR027W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Acetytransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; acetylation of cohesin subunits antagonizes Rad61p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 281 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromatin [IPILink to PubMed article]
    Biological Process: DNA repair [IDALink to PubMed article]
    DNA replication [IMPLink to PubMed article]
    mitotic sister chromatid cohesion [IMPLink to PubMed article]
    Molecular Function: acetyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKARKSQRKA GSKPNLIQSK LQVNNGSKSN KIVKCDKCEM SYSSTSIEDR AIHEKYHTLQ  60
   61 LHGRKWSPNW GSIVYTERNH SRTVHLSRST GTITPLNSSP LKKSSPSITH QEEKIVYVRP 120
  121 DKSNGEVRAM TEIMTLVNNE LNAPHDENVI WNSTTEEKGK AFVYIRNDRA VGIIIIENLY 180
  181 GGNGKTSSRG RWMVYDSRRL VQNVYPDFKI GISRIWVCRT ARKLGIATKL IDVARENIVY 240
  241 GEVIPRYQVA WSQPTDSGGK LASKYNGIMH KSGKLLLPVY I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ECO1 PPZ2 2 Unpublished Fields Lab Data
    View Screen ECO1 MPS3 2 Unpublished Fields Lab Data
    View Screen ECO1 PET494 2 Unpublished Fields Lab Data
    View Screen ECO1 VPS45 1 Unpublished Fields Lab Data
    View Screen ECO1 SML1 1 Unpublished Fields Lab Data
    View Screen ECO1 VPS9 1 Unpublished Fields Lab Data
    View Screen YKU80 ECO1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ECO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] MSA 2.010983 View MSA. No confident structure predictions are available.
    2 View Details [150..281] MSA 1.009969 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  6.13726698303784 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  6.10795007254096 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  6.10795007254096 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  6.01466152555751 bayes_pls_golite062009
  • acetyltransferase activity
    		•  5.43477850446545 bayes_pls_golite062009
  • acyltransferase activity
    		•  4.18713192358082 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.17218293420277 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  4.15740086660902 bayes_pls_golite062009
    		• 3.50745927124371 bayes_pls_golite062009
  • transferase activity
    		•  2.55875279009494 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.00585931208838 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.84222336692632 bayes_pls_golite062009
  • catalytic activity
    		•  1.823104805379 bayes_pls_golite062009
  • binding
    		•  1.30356860355657 bayes_pls_golite062009
  • histone acetyltransferase activity (H4-K16 specific)
    		•  1.29613772727702 bayes_pls_golite062009
  • transcription factor binding
    		•  0.979373407676949 bayes_pls_golite062009
  • transcription activator activity
    		•  0.720181147869432 bayes_pls_golite062009
  • myristoyltransferase activity
    		•  0.333301232703043 bayes_pls_golite062009
  • glycylpeptide N-tetradecanoyltransferase activity
    		•  0.333301232703043 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.145072909584961 bayes_pls_golite062009
  • protein binding
    		•  0.116359302536336 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle