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Protein Overview: HXT3

General Information:
Name(s) found: HXT3 / YDR345C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 567 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISSLink to PubMed article]
    Biological Process: hexose transport [TASLink to PubMed article]
    Molecular Function: fructose transmembrane transporter activity [TASLink to PubMed article]
    glucose transmembrane transporter activity [IDALink to PubMed article][TASLink to PubMed article]
    mannose transmembrane transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSTPDLISP QKSSENSNAD LPSNSSQVMN MPEEKGVQDD FQAEADQVLT NPNTGKGAYV  60
   61 TVSICCVMVA FGGFVFGWDT GTISGFVAQT DFLRRFGMKH KDGSYYLSKV RTGLIVSIFN 120
  121 IGCAIGGIIL AKLGDMYGRK MGLIVVVVIY IIGIIIQIAS INKWYQYFIG RIISGLGVGG 180
  181 IAVLSPMLIS EVAPKEMRGT LVSCYQLMIT LGIFLGYCTN FGTKNYSNSV QWRVPLGLCF 240
  241 AWALFMIGGM TFVPESPRYL VEAGQIDEAR ASLSKVNKVA PDHPFIQQEL EVIEASVEEA 300
  301 RAAGSASWGE LFTGKPAMFK RTMMGIMIQS LQQLTGDNYF FYYGTTVFNA VGMSDSFETS 360
  361 IVFGVVNFFS TCCSLYTVDR FGRRNCLLYG AIGMVCCYVV YASVGVTRLW PNGEGNGSSK 420
  421 GAGNCMIVFA CFYIFCFATT WAPIAYVVIS ETFPLRVKSK AMSIATAANW LWGFLIGFFT 480
  481 PFITGAINFY YGYVFMGCMV FAYFYVFFFV PETKGLTLEE VNDMYAEGVL PWKSASWVPT 540
  541 SQRGANYDAD ALMHDDQPFY KKMFGKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) HXT1 HXT3 HXT4 HXT8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HXT3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..254]
    [303..514]    		 PSI-BLAST 472.218487 No description for 1ja5A_ was found.
    2 View Details [255..302]
    [515..567]    		 PSI-BLAST 472.218487 No description for 1ja5A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glycerol transmembrane transporter activity
    		•  7.11654923455995 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  6.7545566917184 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  6.7545566917184 bayes_pls_golite062009
  • glycerol-3-phosphate transmembrane transporter activity
    		•  5.74077413704789 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • hexose phosphate transmembrane transporter activity
    		•  3.3746965264994 bayes_pls_golite062009
  • glucose-6-phosphate transmembrane transporter activity
    		•  3.3746965264994 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  2.99050613058546 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  2.99050613058546 bayes_pls_golite062009
  • monosaccharide transmembrane transporter activity
    		•  2.63293544825311 bayes_pls_golite062009
  • carbohydrate transmembrane transporter activity
    		•  2.62141276633776 bayes_pls_golite062009
  • sugar transmembrane transporter activity
    		•  2.47557586092261 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • solute:hydrogen symporter activity
    		•  2.10485633822652 bayes_pls_golite062009
  • binding
    		•  1.89539096965643 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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