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Protein Overview: PAM1

General Information:
Name(s) found: PAM1 / YDR251W [SGD]
Description(s) found:
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  • gi|6320457|ref|NP_010537.1| Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; Pam1p [Sacch [NCBI NR]
  • gi|56757611|sp|P37304.2|PAM1_YEAST RecName: Full=Protein PAM1 [NCBI NR]
  • pir||S54547 PAM1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Protein PAM1 OS=Saccharomyces cerevisiae GN=PAM1 PE=1 SV=2 [Swiss-Prot]
  • PAM1 Coiled-coil protein multicopy suppressor of loss of PP2A [mips]
  • Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype [SGD]
  • PAM1, Chr IV from 960605-963097 [yeast_orfs2]
  • Chr IV from 960605-963097 [yeastorf3.fasta]
  • PAM1 SGDID:S0002659, Chr IV from 960606-963098, Verified ORF [yeastflysequest.fasta]
  • PAM1 SGDID:S0002659, Chr IV from 960608-963100, Verified ORF [10112005cervSGD.fasta]
  • Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype [Saccharomyces cerevisiae]gi|2132380|pir [nrdb_11152004_Chlamydomonas]
  • PAM1 SGDID:S000002659, Chr IV from 960608-963100, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PAM1 SGDID:S000002659, Chr IV from 960610-963102, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces [yeast-contam.fasta]
  • PAM1 SGDID:S000002659, Chr IV from 960611-963103, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; Pam1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein PAM1 [nr-271106-contam.fasta]
  • PAM1 SGDID:S000002659, Chr IV from 960611-963103, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype" [yeast-bovrabprots.fasta]
  • PAM1 SGDID:S000002659, Chr IV from 960610-963102, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Protein PAM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAM1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PAM1 SGDID:S000002659, Chr IV from 960614-963106, Genome Release 64-1-1, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype" [yeast-030211-contam.fasta]
  • PAM1 SGDID:S000002659, Chr IV from 960614-963106, Genome Release 64-2-1, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; PAM1 has a paralog, SVL3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDR251W SGDID:S000002659, Chr IV from 960614-963106, Genome Release 64-1-1, Verified ORF, "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 830 amino acids

    Gene Ontology:
    Cellular Component: cellular bud [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    Biological Process: pseudohyphal growth [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSALRVLVC GDHPNLILYT SRFQHAKNIE FYLVNNSKNA NYEVSSLFYG TERFQIQNHF  60
   61 QSLLDLVDLN NENGGLVFDL IIMSASSLQE IPQVLRDIKP MMNKTTKILF ESSGFIYLEP 120
  121 FIKASVDLSL SNIFSIFTDY DIRRLDNGSY KQFTTANAKS FSVSIGQTTS VHENSYSSDI 180
  181 IPILNTFQKL FQKLFPRDVV TLYDHSPSAF LAKEWELALP QICFDPLLII LEEKNPSTLD 240
  241 DHVLAKPLIS GLLGESLLII KKMGIAMNNP NFQNEQTILK HWKNKCEDLP DGPALLYNFI 300
  301 HKASSLNIDL LLLQPILLAD DFGVKTPYLE CLFTMMTQYQ LLNKGDSEWF IRKDENTALT 360
  361 RVDDLQNSIA LKDGKIMQLQ NSESTLKNEI KELQSQVLSL KQEVSSSKAN NGQELEILKK 420
  421 KVQMGDNSLF DRPNSNTNGI SPSDNIVDVD LNYERSDQGN NSSGNDSRRQ SFFNSTSDTT 480
  481 LSRDETSLKE RELEVRMKEL ELQERELELQ RKALQQQQQY QQRPPKQVYS GPSGTPTSGN 540
  541 NNNKSYNPNR KSSYSQPQHV AMMTSRGLHG PSAASSSPVI SANNFVDPVS SGTPYSSNSS 600
  601 RFSQQIPSQQ YMHTVKPTSR KNRSSVMPNI GYVPGLTNNE YGRKFNGNGM NGTQSRLNSL 660
  661 SNQSTFRSQQ GPPITQQKSF QNNGGSMRTN RIPSANYNIS NQQSGFVNSI SSPNLSNLEN 720
  721 RNTVQNSRNA DSAPCVNQLN SDSPPQLQSL SQNGTSKVPQ INITQPSPIQ TNFATSDNPA 780
  781 AVIKLGTPSE DTVSAAATAN NISTMGDESR KEDVKEKKKK KFSFFGKRKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PAM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 39.154902 Ketopantoate reductase PanE
    2 View Details [214..371] PSI-BLAST 39.154902 Ketopantoate reductase PanE
    3 View Details [372..461] deduced N/A No confident structure predictions are available.
    4 View Details [462..830] ORFEUS 7.06 RBP1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle