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Protein Overview: GTB1

General Information:
Name(s) found: GTB1 / YDR221W [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 702 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: polysaccharide biosynthetic process [IMPLink to PubMed article]
    protein amino acid N-linked glycosylation [IMPLink to PubMed article]
    Molecular Function: alpha-glucosidase activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSMFSLFLL LIEQSPLVAS LQQSQRHIVG VPWEKQHLYD SNEPDLTKWH CLNHEDIVLD  60
   61 ISQINDGVCD CPDGSDEPGS AACVEDIFKS VAEGGGKVNK YFYCDNKGFI PRYIRKSEVA 120
  121 DGICDCCDCS DELLSGYELF DAGSNCSQLK NEFDIMASKE LSSYREGKEA LEELERKYGT 180
  181 KEEAITRGNC LEEDKEKASA EIKVLSNRLS ENRAKLEQLR GEYFNQLSHD PILYQFEQLN 240
  241 STRLGSDILT SFTMVSRVSK GYQDIFKILS DLSEAYTPSL NDKVVNDNIK KFRKVRRRAE 300
  301 KAKINADSKI DDEQADNLYL YFTEEVPQIF LKRESENTLR YVIGKSNFVQ ALVEGKINYT 360
  361 NDILEYIREF RLIMDDISQN YNVNFQDAGV KSAVDSYKNY LGEYGELAEL EPAHPSESLL 420
  421 RSLSEVTSFV NENAPKVLPP DAVESEQDTN SDHIGTSGDL RNKLKEILSK LNIFSSRKDL 480
  481 VSLEKRFRSC ESQVSLLENE LKQKMDYKKL LDETEDEGTN STAGNLTELL ELMGSQSYCL 540
  541 DDILDNYVYT ICFQRPMTEG VIYQAEDKVD GKKVLIGRFK TSGFNVDLNM EKYAEHLKAT 600
  601 YDEKSDLISN LAAIQDDDGN MQHYVFGNLN ELNNGLVLEY ENGDQCWNGP RRSATVFVRC 660
  661 SDKFKIRSVH EATKCNYIFD VVGPLGCNKT FEYEPPKFNL SE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GTB1 ROT2
    View Details Krogan NJ, et al. (2006) GTB1 ROT2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GTB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..276] PSI-BLAST 21.522879 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    2 View Details [277..434] deduced N/A No confident structure predictions are available.
    3 View Details [435..560] MSA 1.01899 View MSA. No confident structure predictions are available.
    4 View Details [561..702] ORFEUS 7.88 Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  1.16931544864195 bayes_pls_golite062009
  • protein binding
    		•  0.872890850602389 bayes_pls_golite062009
  • protein kinase activity
    		•  0.583206284003708 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.508369072880209 bayes_pls_golite062009
  • kinase activity
    		•  0.391568627986248 bayes_pls_golite062009
  • catalytic activity
    		•  0.282237710666423 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.210030780379333 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.181223198260708 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle