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Protein Overview: ARG82

General Information:
Name(s) found: ARG82 / YDR173C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 355 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    arginine metabolic process [IMPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    regulation of phosphate metabolic process [IMPLink to PubMed article]
    phosphoinositide phosphorylation [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Molecular Function: inositol polyphosphate multikinase activity [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    phosphoinositide 3-kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTVNNYRVL EHKAAGHDGT LTDGDGLLIF KPAFPQELEF YKAIQVRDVS RRKSSADGDA  60
   61 PLCSWMPTYL GVLNEGAKIE QSGDAALLKI DERLSDSTDN LDSIPVKSEK SKQYLVLENL 120
  121 LYGFSKPNIL DIKLGKTLYD SKASLEKRER MKRVSETTTS GSLGFRICGM KIQKNPSVLN 180
  181 QLSLEYYEEE ADSDYIFINK LYGRSRTDQN VSDAIELYFN NPHLSDARKH QLKKTFLKRL 240
  241 QLFYNTMLEE EVRMISSSLL FIYEGDPERW ELLNDVDKLM RDDFIDDDDD DDDNDDDDDD 300
  301 DAEGSSEGPK DKKTTGSLSS MSLIDFAHSE ITPGKGYDEN VIEGVETLLD IFMKF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ARG80 ARG81 ARG82 MCM1
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ARG82 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..355] Pfam 132.585027 Inositol polyphosphate kinase No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle