Protein Overview: CDC37

General Information:
Name(s) found:	CDC37 / YDR168W [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding [SGD]
Organism:	Saccharomyces cerevisiae
Length:	506 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	MAPKKK cascade involved in osmosensory signaling pathway [IMP][IPI] regulation of stress-activated MAPK cascade [IMP][IPI] spindle pole body duplication in nuclear envelope [IGI][IMP]
Molecular Function:	unfolded protein binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIDYSKWDK IELSDDSDVE VHPNVDKKSF IKWKQQSIHE QRFKRNQDIK NLETQVDMYS  60
   61 HLNKRVDRIL SNLPESSLTD LPAVTKFLNA NFDKMEKSKG ENVDPEIATY NEMVEDLFEQ 120
  121 LAKDLDKEGK DSKSPSLIRD AILKHRAKID SVTVEAKKKL DELYKEKNAH ISSEDIHTGF 180
  181 DSSFMNKQKG GAKPLEATPS EALSSAAESN ILNKLAKSSV PQTFIDFKDD PMKLAKETEE 240
  241 FGKISINEYS KSQKFLLEHL PIISEQQKDA LMMKAFEYQL HGDDKMTLQV IHQSELMAYI 300
  301 KEIYDMKKIP YLNPMELSNV INMFFEKVIF NKDKPMGKES FLRSVQEKFL HIQKRSKILQ 360
  361 QEEMDESNAE GVETIQLKSL DDSTELEVNL PDFNSKDPEE MKKVKVFKTL IPEKMQEAIM 420
  421 TKNLDNINKV FEDIPIEEAE KLLEVFNDID IIGIKAILEN EKDFQSLKDQ YEQDHEDATM 480
  481 ENLSLNDRDG GGDNHEEVKH TADTVD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		CDC10 CDC11 CDC12 CDC3 CDC37 SHS1
View Details	Gavin AC, et al. (2006)		ATP3 CDC37
View Details	Ho Y, et al. (2002)		CDC37 CTK1 GBP2 HHF1, HHF2 HRB1 KRE33 NPL3 SFP1 SIT4

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	BEM1	CDC37	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CDC37	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..95] [157..506]	ORFEUS	7.53	5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
2	View Details	[96..156]	ORFEUS	7.53	5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
unfolded protein binding	2.81356017403888	bayes_pls_golite062009
binding	2.27048396817643	bayes_pls_golite062009
protein binding	2.017826082168	bayes_pls_golite062009
chaperone binding	1.0201051634973	bayes_pls_golite062009
protein kinase regulator activity	0.88466785845109	bayes_pls_golite062009
kinase regulator activity	0.73391412820573	bayes_pls_golite062009
heat shock protein binding	0.37877224532954	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2