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View Structure Prediction Details

Protein: CDC37
Organism: Saccharomyces cerevisiae
Length: 506 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC37.

Description E-value Query
Range		 Subject
Range
CDC37_YEAST - Hsp90 co-chaperone Cdc37 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC37 PE=1 SV=2
CDC37 - Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stab...
gi|151942150 - gi|151942150|gb|EDN60506.1| co-chaperone [Saccharomyces cerevisiae YJM789]
gi|207346650 - gi|207346650|gb|EDZ73088.1| YDR168Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190404878 - gi|190404878|gb|EDV08145.1| Hsp90 co-chaperone Cdc37 [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..506] [1..506]
CDC37_CANAL - Hsp90 co-chaperone Cdc37 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC37 PE=3 SV=1
CDC37_CANAL, CC3... - Hsp90 co-chaperone Cdc37 OS=Candida albicans GN=CDC37 PE=3 SV=1, (Q8X1E6) Hsp90 co-chaperone Cdc37 (...
 0.0 [1..481] [1..496]
CDC37_SCHPO - Hsp90 co-chaperone Cdc37 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cdc37 PE=1 SV=1
cdc37 - Hsp90 co-chaperone Cdc37
 0.0 [1..462] [1..458]
gi|16758570, gi|... - gi|16758570|ref|NP_446195.1| cell division cycle 37 homolog [Rattus norvegicus], gi|1197180|dbj|BAA0...
 2.0E-94 [3..439] [2..330]
CDC37_MOUSE - Hsp90 co-chaperone Cdc37 OS=Mus musculus GN=Cdc37 PE=1 SV=1
 5.0E-92 [3..439] [2..330]
CDC37 - cell division cycle 37 homolog (S. cerevisiae)
ENSMMUT000000044... - null, null
gi|60816049, gi|... - gi|61358261|gb|AAX41537.1| CDC37 cell division cycle 37-like [synthetic construct], gi|60816049|gb|A...
 2.0E-90 [3..439] [2..329]
CDC37_CHICK - Hsp90 co-chaperone Cdc37 OS=Gallus gallus GN=CDC37 PE=2 SV=1
 3.0E-87 [3..439] [2..334]
CDC37_TETFL - Hsp90 co-chaperone Cdc37 OS=Tetraodon fluviatilis GN=cdc37 PE=3 SV=1
 2.0E-75 [3..477] [4..372]
Cdc37-PA - The gene Cdc37 is referred to in FlyBase by the symbol Dmel\Cdc37 (CG12019, FBgn0011573). It is a pr...
 2.0E-73 [3..440] [2..326]

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Predicted Domain #1
Region A:
Residues: [1-95] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIDYSKWDK IELSDDSDVE VHPNVDKKSF IKWKQQSIHE QRFKRNQDIK NLETQVDMYS  60
   61 HLNKRVDRIL SNLPESSLTD LPAVTKFLNA NFDKM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [157-506] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKKLDELYKE KNAHISSEDI HTGFDSSFMN KQKGGAKPLE ATPSEALSSA AESNILNKLA  60
   61 KSSVPQTFID FKDDPMKLAK ETEEFGKISI NEYSKSQKFL LEHLPIISEQ QKDALMMKAF 120
  121 EYQLHGDDKM TLQVIHQSEL MAYIKEIYDM KKIPYLNPME LSNVINMFFE KVIFNKDKPM 180
  181 GKESFLRSVQ EKFLHIQKRS KILQQEEMDE SNAEGVETIQ LKSLDDSTEL EVNLPDFNSK 240
  241 DPEEMKKVKV FKTLIPEKMQ EAIMTKNLDN INKVFEDIPI EEAEKLLEVF NDIDIIGIKA 300
  301 ILENEKDFQS LKDQYEQDHE DATMENLSLN DRDGGGDNHE EVKHTADTVD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1bgxT
Description: 5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [96-156] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKSKGENVDP EIATYNEMVE DLFEQLAKDL DKEGKDSKSP SLIRDAILKH RAKIDSVTVE  60
   61 A

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.53
Match: 1bgxT
Description: 5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 2.81356017403888 bayes_pls_golite062009
binding 2.27048396817643 bayes_pls_golite062009
protein binding 2.017826082168 bayes_pls_golite062009
chaperone binding 1.0201051634973 bayes_pls_golite062009
protein kinase regulator activity 0.88466785845109 bayes_pls_golite062009
kinase regulator activity 0.73391412820573 bayes_pls_golite062009
heat shock protein binding 0.37877224532954 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle