Protein Overview: TMS1

General Information:
Name(s) found:	TMS1 / YDR105C [SGD]
Description(s) found: Found 33 descriptions. SHOW ALL	Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance [SGD]
Organism:	Saccharomyces cerevisiae
Length:	473 amino acids
Gene Ontology:
Cellular Component:	membrane [ISS] vacuolar membrane [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAVISLPVS MAGSFVASCF GGCCSNLVTK TASSLGSSSL GTRLLYAVWL LLNSLISWVS  60
   61 YSANKSILWP GKTCTGTGEC GFFTVHRLNF ALGCLHLILA LVLTGVKSTN DVRAALQNSW 120
  121 WSLKFILYLC LIVLSFVIPN DFYIFFSKWV SVPSGAIFIL VGLILLVDFA HEWAETCISH 180
  181 VESEDEDSSF WQRFLVLGTT SMYTASIIMT VVMYVMFCHQ QCNMNQTAVT VNLILTVITL 240
  241 VLSVNPKIQE ANPKSGLAQS SMVSVYCTYL TMSAMSSEPD DKMCNPLVRS SGTRKFSIIL 300
  301 GSLFTFIAIA YTTTRAAANS AFQGTNTNGA IYLGNDIEYE GLGGQTRNQL RYEAIKQAVE 360
  361 EGSLPESALY DTAWLGTSSP TGAMDNQNDD ERTGTKYNYT LFHVIFFLAT QWIAILLTIN 420
  421 VTQDDVGDFI PVGRTYFYSW VKIVSAWICY ALYGWTVVAP AIMPDRFDYE NYY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	TUP1	TMS1	1	Unpublished Fields Lab Data
View Screen	MDM30	TMS1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	TMS1	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..473]	Pfam	283.387216	TMS membrane protein/tumour differentially expressed protein (TDE) No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2