Protein Overview: ENA2

General Information:
Name(s) found:	ENA2 / YDR039C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|790262\|gb\|AAA65601.1\| Pmr2bp [NCBI NR] gi\|6320244\|ref\|NP_010324.1\| P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux; Ena2p [Saccharomyces cerevisiae] [NCBI NR] gi\|5513\|emb\|CAA47615.1\| P-type ATPase [Saccharomyces cerevisiae] [NCBI NR] gi\|416667\|sp\|Q01896.1\|ATN2_YEAST RecName: Full=Sodium transport ATPase 2 [NCBI NR] gi\|1431488\|emb\|CAA98866.1\| ENA2 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S25007 Ca2+-transporting ATPase (EC 3.6.3.8) ENA2 - yeast (Saccharomyces cerevisiae) [NCBI NR] Sodium transport ATPase 2 OS=Saccharomyces cerevisiae GN=ENA2 PE=1 SV=1 [Swiss-Prot] ENA2 Plasma membrane P-type ATPase involved in Na+ and Li+ efflux [mips] P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux [SGD] ENA2, Chr IV from 531301-534576, reverse complement [yeast_orfs2] Chr IV from 531301-534576, reverse complement [yeastorf3.fasta] Chr IV from 534576-531301, reverse complement [yeastorf5.fasta] (Q01896) Sodium transport ATPase 2 (EC 3.6.3.7) [4932.FASTACCERV.txt] ENA2 SGDID:S0002446, Chr IV from 534577-531302, reverse complement, Verified ORF [yeastflysequest.fasta] ENA2 SGDID:S0002446, Chr IV from 534578-531303, reverse complement, Verified ORF [10112005cervSGD.fasta] Ena2p [Saccharomyces cerevisiae]gi\|1431488\|emb\|CAA98866.1\| ENA2 [Saccharomyces cerevisiae]gi\|416667\|sp\|Q01896\|ATN2_YEAST Sodium transport ATPase 2gi\|101467\|pir\|\|S25007 Ca2+-transporting ATPase (EC 3.6.3.8) ENA2 - yeast (Saccharomyces cerevisiae)gi\|79 [nrdb_11152004_Chlamydomonas] ENA2 SGDID:S000002446, Chr IV from 534578-531303, reverse complement, Verified ORF, "P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ENA2 SGDID:S000002446, Chr IV from 534579-531304, reverse complement, Verified ORF, "P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" [yeast-contam.fasta] ENA2 SGDID:S000002446, Chr IV from 534580-531305, reverse complement, Verified ORF, "P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] ENA2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Sodium transport ATPase 2 [nr-271106-contam.fasta] P-type ATPase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Pmr2bp [nr-271106-contam.fasta] P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux; Ena2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Sodium transport ATPase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENA2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ENA2 SGDID:S000002446, Chr IV from 534582-531307, Genome Release 64-1-1, reverse complement, Verified ORF, "P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" [yeast-030211-contam.fasta] ENA2 SGDID:S000002446, Chr IV from 534582-531307, Genome Release 64-2-1, reverse complement, Verified ORF, "P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" [20141208_orf_trans.fasta] YDR039C SGDID:S000002446, Chr IV from 534582-531307, Genome Release 64-1-1, reverse complement, Verified ORF, "P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	1091 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] plasma membrane [IDA]
Biological Process:	potassium ion transport [IMP] sodium ion transport [IGI ]
Molecular Function:	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [IGI][ISS] sodium-exporting ATPase activity, phosphorylative mechanism [IGI][ISS] potassium-transporting ATPase activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEGTVKENN NEEFNAYHTL TTEEAAEFIG TSLTEGLTQD ESLRRLKAVG ENTLGDDTKI  60
   61 DYKAMVLHQV CNAMIMVLVI SMAISFAVRD WITGGVISFV IAVNVLIGLV QEYKATKTMN 120
  121 SLKNLSSPNA HVIRNGKSET INSKDVVPGD ICLVKVGDTI PADLRLIETK NFDTDESLLT 180
  181 GESLPVSKDA NLVFGKEEET SVGDRLNLAF SSSAVVKGRA KGIVIKTALN SEIGKIAKSL 240
  241 QGDSGLISRD PSKSWLQNTW ISTKKVTGAF LGTNVGTPLH RKLSKLAVLL FWIAVLFAII 300
  301 VMASQKFDVD KRVAIYAICV ALSMIPSSLV VVLTITMSVG AAVMVSRNVI VRKLDSLEAL 360
  361 GAVNDICSDK TGTLTQGKML ARQIWIPRFG TITISNSDDP FNPNEGNVSL IPRFSPYEYS 420
  421 HNEDGDVGIL QNFKDRLYEK DLPEDIDMDL FQKWLETATL ANIATVFKDD ATDCWKAHGD 480
  481 PTEIAIQVFA TKMDLPHNAL TGEKSTNQSN ENDQSSLSQH NEKPGSAQFE HIAEFPFDST 540
  541 VKRMSSVYYN NHNETYNIYG KGAFESIISC CSSWYGKDGV KITPLTDCDV ETIRKNVYSL 600
  601 SNEGLRVLGF ASKSFTKDQV NDDQLKNITS NRATAESDLV FLGLIGIYDP PRNETAGAVK 660
  661 KFHQAGINVH MLTGDFVGTA KAIAQEVGIL PTNLYHYSQE IVDSMVMTGS QFDGLSEEEV 720
  721 DDLPVLPLVI ARCSPQTKVR MIEALHRRKK FCAMTGDGVN DSPSLKMANV GIAMGINGSD 780
  781 VSKEASDIVL SDDNFASILN AVEEGRRMTD NIQKFVLQLL AENVAQALYL IIGLVFRDEN 840
  841 GKSVFPLSPV EVLWIIVVTS CFPAMGLGLE KAAPDLMDRP PHDSEVGIFT WEVIIDTFAY 900
  901 GIIMTGSCMA SFTGSLYGIN SGRLGHDCDG TYNSSCRDVY RSRSAAFATM TWCALILAWE 960
  961 VVDMRRSFFR MHPDTDSPVK EFFRSIWGNQ FLFWSIIFGF VSAFPVVYIP VINDKVFLHK1020
 1021 PIGAEWGLAI AFTIAFWIGA ELYKCGKRRY FKTQRAHNPE NDLESNNKRD PFEAYSTSTT1080
 1081 IHTEVNIGIK Q

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		ENA1 ENA2 MEP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#33 Asynchronous SPB prep	Keck JM, et al. (2011)
View Run	VAM3	Sample: HX11 - both fusion and trans-SNARE complex formation take place.	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control).	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX13 - trans-SNARE complex forms but fusion is blocked.	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX14 - mixture in detergent (control).	Hao Xu, et al. (2010)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	ENA2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..56] [128..258]	PSI-BLAST	1906.9897	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
2	View Details	[57..117] [259..336] [808..1091]	PSI-BLAST	1906.9897	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
3	View Details	[118..127] [337..376] [651..807]	PSI-BLAST	1906.9897	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
4	View Details	[377..650]	PSI-BLAST	1906.9897	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Protein Overview: ENA2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: