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Protein Overview: GUD1

General Information:
Name(s) found: GUD1 / YDL238C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 489 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: guanine metabolic process [ISSLink to PubMed article]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [ISSLink to PubMed article]
    guanine deaminase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSDLLFDK FNDKHGKFLV FFGTFVDTPK LGELRIREKT SVGVLNGIIR FVNRNSLDPV  60
   61 KDCLDHDSSL SPEDVTVVDI IGKDKTRNNS FYFPGFVDTH NHVSQYPNVG VFGNSTLLDW 120
  121 LEKYTFPIEA ALANENIARE VYNKVISKTL SHGTTTVAYY NTIDLKSTKL LAQLSSLLGQ 180
  181 RVLVGKVCMD TNGPEYYIED TKTSFESTVK VVKYIRETIC DPLVNPIVTP RFAPSCSREL 240
  241 MQQLSKLVKD ENIHVQTHLS ENKEEIQWVQ DLFPECESYT DVYDKYGLLT EKTVLAHCIH 300
  301 LTDAEARVIK QRRCGISHCP ISNSSLTSGE CRVRWLLDQG IKVGLGTDVS AGHSCSILTT 360
  361 GRQAFAVSRH LAMRETDHAK LSVSECLFLA TMGGAQVLRM DETLGTFDVG KQFDAQMIDT 420
  421 NAPGSNVDMF HWQLKEKDQM QEQEQEQGQD PYKNPPLLTN EDIIAKWFFN GDDRNTTKVW 480
  481 VAGQQVYQI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AAP1 GUD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GUD1 Huh WK, et al. (2003)
    View Data GUD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..22]
    [41..86]    		 PSI-BLAST 64.69897 alpha-Subunit of urease; alpha-subunit of urease, catalytic domain
    2 View Details [23..40]
    [87..489]    		 PSI-BLAST 64.69897 alpha-Subunit of urease; alpha-subunit of urease, catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • guanine deaminase activity
    		•  3.78802420851729 bayes_pls_golite062009
  • hydrolase activity
    		•  3.06979421893431 bayes_pls_golite062009
  • adenine deaminase activity
    		•  1.93704109004145 bayes_pls_golite062009
  • deaminase activity
    		•  1.79186203771221 bayes_pls_golite062009
  • catalytic activity
    		•  1.70199291046899 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.60895003474033 bayes_pls_golite062009
  • dihydropyrimidinase activity
    		•  1.51712244686012 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
    		•  0.787370269329878 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  0.573107361273483 bayes_pls_golite062009
  • peptidase activity
    		•  0.483675247391628 bayes_pls_golite062009
  • dihydroorotase activity
    		•  0.203044795244555 bayes_pls_golite062009
  • binding
    		•  0.131274900913166 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.0644988334012029 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle