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Protein Overview: NDE2

General Information:
Name(s) found: NDE2 / YDL085W [SGD]
Description(s) found:
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  • gi|74676439|sp|Q07500.1|NDH2_YEAST RecName: Full=External NADH-ubiquinone oxidoreductase 2, mitochondrial; AltName: Full=External NADH dehydrogenase 2; Flags: Precursor [NCBI NR]
  • gi|6320118|ref|NP_010198.1| Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; Nde2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S67621 hypothetical protein YDL085w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1431110|emb|CAA98651.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • External NADH-ubiquinone oxidoreductase 2, mitochondrial OS=Saccharomyces cerevisiae GN=NDE2 PE=1 SV=1 [Swiss-Prot]
  • NDE2 Mitochondrial NADH dehydrogenase that catalyzes the oxidation of cytosolic NADH [mips]
  • Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain [SGD]
  • YDL085W, Chr IV from 303210-304847 [yeast_orfs2]
  • Chr IV from 303210-304847 [yeastorf3.fasta]
  • >Q07500 (Q07500) Chromosome IV reading frame ORF YDL085W [4932.FASTACCERV.txt]
  • NDE2 SGDID:S0002243, Chr IV from 303211-304848, Verified ORF [yeastflysequest.fasta]
  • Nde2p [Saccharomyces cerevisiae]gi|1431110|emb|CAA98651.1| unnamed protein product [Saccharomyces cerevisiae]gi|2131327|pir||S67621 hypothetical protein YDL085w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • (Q07500) S.cerevisiae chromosome IV reading frame ORF YDL085w [cerv4932.FASTAC]
  • NDE2 SGDID:S000002243, Chr IV from 303211-304848, Verified ORF, "Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; Nde2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • External NADH-ubiquinone oxidoreductase 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NDE2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NDE2 SGDID:S000002243, Chr IV from 303211-304848, Genome Release 64-1-1, Verified ORF, "Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain" [yeast-030211-contam.fasta]
  • NDE2 SGDID:S000002243, Chr IV from 303211-304848, Genome Release 64-2-1, Verified ORF, "Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDL085W SGDID:S000002243, Chr IV from 303211-304848, Genome Release 64-1-1, Verified ORF, "Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 545 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: NADH oxidation [IDALink to PubMed article]
    glucose catabolic process to ethanol [IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: NADH dehydrogenase activity [ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPRLGFART ARSIHRFKMT QISKPFFHST EVGKPGPQQK LSKSYTAVFK KWFVRGLKLT  60
   61 FYTTLAGTLY VSYELYKESN PPKQVPQSTA FANGLKKKEL VILGTGWGAI SLLKKLDTSL 120
  121 YNVTVVSPRS FFLFTPLLPS TPVGTIEMKS IVEPVRSIAR RTPGEVHYIE AEALDVDPKA 180
  181 KKVMVQSVSE DEYFVSSLSY DYLVVSVGAK TTTFNIPGVY GNANFLKEIE DAQNIRMKLM 240
  241 KTIEQASSFP VNDPERKRLL TFVVVGGGPT GVEFAAELQD YINQDLRKWM PDLSKEMKVI 300
  301 LIEALPNILN MFDKTLIKYA EDLFARDEID LQVNTAVKVV EPTYIRTLQN GQTNTDIEYG 360
  361 MLVWATGNEP IDFSKTLMSR IPEQTNRRGL LINDKLELLG SENSIYAIGD CTAHTGFFPT 420
  421 AQVAHQEGEY LAKILDKKLQ IEQLEWDMLN STDETEVSRL QKEVNLRKSK LDKFNYKHMG 480
  481 ALAYIGSETA IADLHMGDSS YQLKGMFAFL FWKSAYLAMC LSIRNRILIA MDWTKVYFLG 540
  541 RDSSV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDH2 NDE2 YNR062C
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
    View Details Krogan NJ, et al. (2006) MBR1 NDE2 PIG1 YJL118W
    View Details Qiu et al. (2008) ALD4 NDE1 NDE2 NDI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] deduced N/A No confident structure predictions are available.
    2 View Details [88..210]
    [368..445]    		 PSI-BLAST 85.221849 Dihydrolipoamide dehydrogenase
    3 View Details [211..367]
    [446..545]    		 PSI-BLAST 85.221849 Dihydrolipoamide dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.63

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle