Protein Overview: PTC6

General Information:
Name(s) found:	PTC6 / YCR079W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|49066025\|sp\|P25646.2\|PP2C6_YEAST RecName: Full=Protein phosphatase 2C homolog 6; Short=PP2C-6 [NCBI NR] gi\|14588958\|emb\|CAC42991.1\| hypothetical protein [Saccharomyces cerevisiae] [NCBI NR] gi\|10383808\|ref\|NP_010003.2\| Phosphoprotein phosphatase type 2C similar to mammalian PP1Ks; involved in mitophagy; localized to mitochondrial inner membrane space; null mutant is sensitive to rapamycin; Ptc6p [Saccharomyces cerevisiae] [NCBI NR] (P25646) Protein phosphatase 2C-like protein YCR079W [Swiss-Prot] Protein phosphatase 2C homolog 6 OS=Saccharomyces cerevisiae GN=PTC6 PE=1 SV=2 [Swiss-Prot] Putative protein phosphatase localised to mitochondria [mips] Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase [SGD] YCR079W, Chr III from 252838-254166 [yeast_orfs2] Chr III from 252838-254166 [yeastorf3.fasta] (P25646) Protein phophatase 2C-like protein YCR079W [4932.FASTACCERV.txt] YCR079W SGDID:S0002133, Chr III from 252841-254169, Uncharacterized ORF [yeastflysequest.fasta] Ycr079wp [Saccharomyces cerevisiae]gi\|14588958\|emb\|CAC42991.1\| hypothetical protein [Saccharomyces cerevisiae]gi\|49066025\|sp\|P25646\|YCW9_YEAST Protein phophatase 2C-like protein YCR079W [nrdb_11152004_Chlamydomonas] YCR079W SGDID:S000002133, Chr III from 252841-254169, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] PTC6 SGDID:S000002133, Chr III from 252842-254170, Verified ORF, "Phosphoprotein phosphatase type 2C; contains mitochondrial targeting sequence; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutant is sensitive to rap [yeast-contam.fasta] PTC6 SGDID:S000002133, Chr III from 252842-254170, Verified ORF, "Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 s [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Protein phosphatase 2C-like protein YCR079W [nr-271106-contam.fasta] Phosphoprotein phosphatase type 2C; contains mitochondrial targeting sequence; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutant is sensitive to rapamycin; Ptc6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] hypothetical protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] PTC6 SGDID:S000002133, Chr III from 252842-254170, Verified ORF, "Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase" [yeast-bovrabprots.fasta] PTC6 SGDID:S000002133, Chr III from 252842-254170, Verified ORF, "Phosphoprotein phosphatase type 2C; contains mitochondrial targeting sequence; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutant is sensitive to rapamycin" [yeast-contam_custom.fasta] [chemostatdb.fasta] Protein phosphatase 2C homolog 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTC6 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PTC6 SGDID:S000002133, Chr III from 252845-254173, Genome Release 64-1-1, Verified ORF, "Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase" [yeast-030211-contam.fasta] [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTC6 PE=1 SV=2 [YEAST.fasta.20131015] PTC6 SGDID:S000002133, Chr III from 252845-254173, Genome Release 64-2-1, Verified ORF, "Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase" [20141208_orf_trans.fasta] TR6588\|c0_g1_i1\|g.4669 ORF TR6588\|c0_g1_i1\|g.4669 TR6588\|c0_g1_i1\|m.4669 type:complete len:443 (+) TR6588\|c0_g1_i1:66-1394(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YCR079W SGDID:S000002133, Chr III from 252845-254173, Genome Release 64-1-1, Verified ORF, "Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_9198\|g.6620 ORF asmbl_9198\|g.6620 asmbl_9198\|m.6620 type:complete len:443 (+) asmbl_9198:73-1401(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_9206\|g.5524 ORF ID=asmbl_9206\|g.5524 ID=asmbl_9206\|m.5524 type:complete len:443 (+) ID=asmbl_9206:73-1401(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	442 amino acids
Gene Ontology:
Cellular Component:	mitochondrial intermembrane space [IDA] mitochondrion [IDA]
Biological Process:	mitochondrion degradation [IMP] macroautophagy [IGI]
Molecular Function:	protein serine/threonine phosphatase activity [IDA] phosphoprotein phosphatase activity [IEA] catalytic activity [IEA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLGNAYAYC KPSQNVGLKL DLLRGLPGYV GHATSRINRL ENQDNYSIKM MRSWPNAYGS  60
   61 ALNCSVFDGH GEKGAQLSQL LADKLCSSLD FPEPSWDKQD LKKLVQEYAR RFPEGNYWKH 120
  121 KLSTFEKFYN KFIKNCNSKQ ELLLMKEGDS AILGQNGGRM IFDKMGNIID KIALLTELDR 180
  181 LRLFYGFARF DLDQCCGLGT AAGSTASSIF LYPYDDPNAP IDEGKDDDSW IISHSGLLKL 240
  241 IVTQVGDSKI ILCDQDGIAH ALTTTHHINS SRERHRLSID PSRLDPDAFG ETRFLNNFAN 300
  301 TRSFGDVAGK PYGISSEPDI FSFLVGNTLH LPRSERSKLP FNGDECFLAL VTDGITNKLA 360
  361 DQEVVDLITS TVNSWGLKKA TPQFVAEETI KFIQAIATKH SDNATCVVVR LSNWGNWPNV 420
  421 DRTGPQRETK LMNAQSNETK LN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		PRO2 PTC6
View Details	Krogan NJ, et al. (2006)		CIT2 PEP3 PRO2 PTC6
View Details	Gavin AC, et al. (2002)		PRO2 PTC6
View Details	Ho Y, et al. (2002)		CDC60 DEF1 FAA1 GDE1 HEF3 KGD1 MDH1 PRO2 PTC6 PYC1 RAD1 TIF1, TIF2 TPS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SUI1	PTC6	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PTC6	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..93]	deduced	N/A	No confident structure predictions are available.
2	View Details	[94..442]	PSI-BLAST	68.0	Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2