YRC Public Data Repository - Protein Structure Prediction

Protein:	PTC6
Organism:	Saccharomyces cerevisiae
Length:	442 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTC6.

Description	E-value	Query Range	Subject Range
gi\|151943891 - gi\|151943891\|gb\|EDN62191.1\| protein phosphatase type 2C [Saccharomyces cerevisiae YJM789] PDP2_YEAST - [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial OS=Saccharomyces cerevis... PTC6 - Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitopha...	8.0E-96	[1..442]	[1..442]
PPM1A_BOVIN - Protein phosphatase 1A OS=Bos taurus GN=PPM1A PE=2 SV=1	3.0E-68	[108..438]	[22..315]
PPM1A_RAT - Protein phosphatase 1A OS=Rattus norvegicus GN=Ppm1a PE=1 SV=1	1.0E-67	[108..438]	[22..315]
P2C21_ARATH - Probable protein phosphatase 2C 21 OS=Arabidopsis thaliana GN=PPC4-2 PE=1 SV=1	2.0E-67	[89..425]	[1..343]
PPM1A_RABIT - Protein phosphatase 1A OS=Oryctolagus cuniculus GN=PPM1A PE=2 SV=1	2.0E-67	[108..436]	[22..313]
gi\|12005898, gi\|... - gi\|26345004\|dbj\|BAC36151.1\| unnamed protein product [Mus musculus], gi\|12005898\|gb\|AAG44661.1\|AF2596...	2.0E-67	[108..441]	[22..318]
CCDS9744.1_1 - null PPM1A - protein phosphatase, Mg2+/Mn2+ dependent, 1A gi\|114653343, gi... - gi\|114653347\|ref\|XP_509986.2\| PREDICTED: hypothetical protein LOC452950 isoform 9 [Pan troglodytes],... gi\|109083826, gi... - gi\|109083828\|ref\|XP_001096358.1\| PREDICTED: similar to protein phosphatase 1A isoform 1 isoform 5 [M... gi\|123996549, gi... - gi\|168279063\|dbj\|BAG11411.1\| protein phosphatase 1A [synthetic construct], gi\|123996549\|gb\|ABM85876....	4.0E-67	[108..436]	[22..313]

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Predicted Domain #1

Region A:
Residues: [1-93]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLGNAYAYC KPSQNVGLKL DLLRGLPGYV GHATSRINRL ENQDNYSIKM MRSWPNAYGS  60
   61 ALNCSVFDGH GEKGAQLSQL LADKLCSSLD FPE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [94-442]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSWDKQDLKK LVQEYARRFP EGNYWKHKLS TFEKFYNKFI KNCNSKQELL LMKEGDSAIL  60
   61 GQNGGRMIFD KMGNIIDKIA LLTELDRLRL FYGFARFDLD QCCGLGTAAG STASSIFLYP 120
  121 YDDPNAPIDE GKDDDSWIIS HSGLLKLIVT QVGDSKIILC DQDGIAHALT TTHHINSSRE 180
  181 RHRLSIDPSR LDPDAFGETR FLNNFANTRS FGDVAGKPYG ISSEPDIFSF LVGNTLHLPR 240
  241 SERSKLPFNG DECFLALVTD GITNKLADQE VVDLITSTVN SWGLKKATPQ FVAEETIKFI 300
  301 QAIATKHSDN ATCVVVRLSN WGNWPNVDRT GPQRETKLMN AQSNETKLN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	68.0
Match:	1a6q__
Description:	Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits