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Protein Overview: PRD1

General Information:
Name(s) found: PRD1 / YCL057W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 712 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial intermembrane space [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article][TASLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: proteolysis [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: metalloendopeptidase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    saccharolysin activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLLCKNWF ASPVISPLLY TRSLYSMANT TSFPIAPQAP PNWSFTPSDI SGKTNEIINN  60
   61 SNNFYDSMSK VESPSVSNFV EPFMKFENEL GPIINQLTFL QHVSSDKEIR DASVNSSMKL 120
  121 DELNIDLSLR HDIFLQFARV WQDVQSKADS VERETFKYVE KSYKDYIHSG LELDEGNRLK 180
  181 IKEIKKKISV NSINFSKNLG EQKEYITFTK EQLEGVPDSI LTQFETIKSD KDSNETLYKV 240
  241 TFKYPDIFPV MKLASSAQTR KQAFLADQNK VPENEAILLD TLKLRDELAS LLGYDTYANY 300
  301 NLYDKMAEDS TTVMNFLNDL KDKLIPLGRK ELQVLQDMKA EDVKKLNQGA DPNYYIWDHR 360
  361 YYDNKYLLEN FNVDLEKISE YFPLEATITG MLEIYETLFN LKFIETKDSQ NKSVWHDDVK 420
  421 QIAVWNMDDP KSPNFVGWIY FDLHPRDGKY GHAANFGLSS SFMIDDTTRS YPVTALVCNF 480
  481 SKSTKDKPSL LKHNEIVTFF HELGHGIHDL VGQNKESRFN GPGSVPWDFV EAPSQMLEFW 540
  541 TWNKNELINL SSHYKTGEKI PESLINSLIK TKHVNGALFT LRQLHFGLFD MKVHTCKDLQ 600
  601 NLSICDTWNQ LRQDISLISN GGTLSKGYDS FGHIMSDSYS AGYYGYLWAE VFATDMYHTK 660
  661 FAKDPLNAKN GIQYRDIVLA RGGLYDINDN LKEFLGREPS KDAFLKELGL QN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HUL4 MCK1 PRD1 YGR012W
    View Details Qiu et al. (2008) CYM1 PRD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen IST3 PRD1 1 Unpublished Fields Lab Data
    View Screen UBC7 PRD1 1 Unpublished Fields Lab Data
    View Screen ARG1 PRD1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PRD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..42]
    [372..573]
    [646..712]    		 PSI-BLAST 2130.0 Neurolysin (endopeptidase 24.16)
    2 View Details [43..371]
    [574..645]    		 PSI-BLAST 2130.0 Neurolysin (endopeptidase 24.16)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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