Protein Overview: BIT2

General Information:
Name(s) found:	BIT2 / YBR270C [SGD]
Description(s) found: Found 23 descriptions. SHOW ALL	Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	545 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATDLNRKRS ATSGSLSVTN PNIKATNRKP ARVYSVSSDI VPQALTHPDE DVHLKTSKSP  60
   61 HDAAPRWSQV GFQSIFHDGS NARRSTDSIE EEYSQGTENN DGHSEIGSSS SNRMEGNTTS 120
  121 NDSLFSSNSR GNKRRLSIFT NSKDNMRNRS RRASKNYGTV ITGTSSNNIS RSGSKLFHTK 180
  181 SNMSVNSLQS SLSTGHSHSN KGSNVFSKMA KKLLPYKPHN SIGKDDVEPV VPSPFSKFLH 240
  241 SSYGKHRSPV QFIHTSTGGL IDSGKSVYSF NPSINNNPND TALSLIQDDA FDATNVSLLH 300
  301 DLLKNLPSLI ANYKSFTVQE LFVLEGNIWG IYCSIVVELF KNKRVWQLPA KIEDIDRLLE 360
  361 FYITLKTQTK AAVTHSRFLA EIEEFITTSL YILENQIVFN YANEDTVNTA LKRVGIIWKV 420
  421 FYQQVYYDMM AVLLPFEKSF QKNSNYWLDG YLSEPSRYAP SIDVLLLKCF RDSIILPYYE 480
  481 SFLHTNDGAS KSFQRYIFSE EEQNGVTEED KLTLLQCFGI LNTIKGNSRN QRIIGELLEG 540
  541 IRMSI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	LST8	No Comments	Reinke A, et al. (2004)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PRE4	BIT2	2	Unpublished Fields Lab Data
View Screen	MYO1	BIT2	2	Unpublished Fields Lab Data
View Screen	MET30	BIT2	2	Uetz P, et al. (2000)
View Screen	IMP4	BIT2	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..545]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.88

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2